304468-42-6

Basic information

• Product Name: 5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one
• Synonyms: 5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one;5'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one;Spiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one, 5'-broMo-
• CAS NO: 304468-42-6
• Molecular Formula: C₁₃H₁₄BrNO
• Molecular Weight: 280.164
• Mol File: 304468-42-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 196-199 °C
• Boiling Point: 430.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.16±0.20(Predicted)
• CAS DataBase Reference: 5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one(304468-42-6)
• EPA Substance Registry System: 5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one(304468-42-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 304468-42-6(Hazardous Substances Data)

Usage

General Description

5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one is a chemical compound with the molecular formula C15H16BrNO. It is a spiro compound containing a cyclohexane ring and an indole ring fused together, with a bromine atom attached to the 5' position. 5'-Bromospiro[cyclohexane-1,3'-indol]-2'(1'H)-one has potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activities. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 4933-14-6 spiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one 
• 111-24-0 1,5-dibromo-pentane 
• 20870-78-4 5-bromo-2-indolin-2-one 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 59-48-3 2-oxoindole 
• 628-77-3 1,5-diiodopentane 

Downstream Products

• 304874-75-7 5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-[3H]indole]-2'(1'H)-one 
• 304875-02-3 3-(1',2'-Dihydro-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzonitrile 
• 304875-03-4 3-(1',2'-dihydro-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)-5-fluorobenzonitrile 
• 304874-70-2 3-(1',2'-Dihydro-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzaldehyde 

Relevant articles and documents

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)- 1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported

Purification of progesterone receptor modulators

Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.

Indoline derivatives

This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, having the general structure: wherein R1and R2may be single substituents or fused to form spirocyclic rings.