304477-41-6

Basic information

• Product Name: 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde
• Synonyms: 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde;1H-Pyrazole-4-carboxaldehyde, 1-methyl-3-(4-methylphenyl)-
• CAS NO: 304477-41-6
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200
• Mol File: 304477-41-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 365.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: -0.17±0.10(Predicted)
• CAS DataBase Reference: 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde(304477-41-6)
• EPA Substance Registry System: 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde(304477-41-6)

Safety Data

• Hazardous Substances Data: 304477-41-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde is a chemical compound with the molecular formula C12H12N2O. It is a aromatic aldehyde with a pyrazole ring and a p-tolyl group, as well as a methyl group attached to the nitrogen atom. 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is also used as a reagent in organic synthesis, particularly in the preparation of heterocyclic compounds. Additionally, it exhibits potential biological activity and has been studied for its potential use in pharmaceutical applications.

Upstream product

• 350988-62-4 3-(p-tolyl)-1H-pyrazole-4-carboxaldehyde 
• 74-88-4 methyl iodide 
• 3352-98-5 p-methyl acetophenone semicarbazone 
• 122-00-9 para-methylacetophenone 

Relevant articles and documents

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.