3045-32-7

Basic information

• Product Name: 2-(2-hydroxypropan-2-yl)phenol
• Synonyms: 2-(2-hydroxypropan-2-yl)phenol;o-Hydroxy-α,α-diMethylbenzyl Alcohol;2-(2-HYDROXYPROPAN-2-YL)PHENOL(WX191756)
• CAS NO: 3045-32-7
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19038
• Mol File: 3045-32-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 41-44 °C
• Boiling Point: 252.7±7.0 °C(Predicted)
• Appearance: /
• Density: 1.122±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol (Slightly)
• PKA: 10.15±0.35(Predicted)
• CAS DataBase Reference: 2-(2-hydroxypropan-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxypropan-2-yl)phenol(3045-32-7)
• EPA Substance Registry System: 2-(2-hydroxypropan-2-yl)phenol(3045-32-7)

Safety Data

• Hazardous Substances Data: 3045-32-7(Hazardous Substances Data)

Usage

Description

2-(2-hydroxypropan-2-yl)phenol, also known as o-Hydroxy-α,α-dimethylbenzyl Alcohol, is an organic compound with a unique chemical structure that features a phenol group and a hydroxypropan-2-yl side chain. This molecule is characterized by its ability to act as an intermediate in various chemical reactions, particularly in the synthesis of other compounds.

Uses

Used in Chemical Synthesis:
2-(2-hydroxypropan-2-yl)phenol is used as an intermediate in the chemical synthesis process for the preparation of 2,4’-Bisphenol A (B519490), a derivative that is specifically utilized in the production of low-molecular-weight epoxy resins. Its role in this synthesis is crucial, as it serves as a building block for the final product, contributing to the development of materials with specific properties and applications.
Used in Epoxy Resin Industry:
In the epoxy resin industry, 2-(2-hydroxypropan-2-yl)phenol is used as a key component in the production of low-molecular-weight epoxy resins. These resins are known for their excellent adhesion, mechanical properties, and chemical resistance, making them ideal for a wide range of applications, including coatings, adhesives, electrical laminates, and composite materials. The use of 2-(2-hydroxypropan-2-yl)phenol in this industry is driven by its ability to contribute to the development of high-quality epoxy resins with desirable characteristics for various end-use applications.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 27701-23-1 methyl 2-(methoxymethyloxy)benzoate 
• 119-36-8 methyl salicylate 
• 10277-93-7 2-isopropenylphenol 
• 118-93-4 o-hydroxyacetophenone 
• 917-54-4 methyllithium 
• 77023-21-3 1-(hydroxymethyl)benzene oxide 
• 77023-22-4 1-(2-hydroxy-2-propyl)benzene oxide 
• 95-56-7 2-hydroxybromobenzene 
• 67-64-1 acetone 
• 676-58-4 methylmagnesium chloride 
• 32937-33-0 1-(hydroxymethyl)cyclohexa-1,4-diene 
• 77023-02-0 1-(hydroxymethyl)-1,2-oxido-4-cyclohexene 

Downstream Products

• 10277-93-7 2-isopropenylphenol 
• 82466-10-2 2,4,4-Trimethyl-4H-benzo[1,3]dioxine 
• 137408-18-5 2-[2-(1-Hydroxy-1-methyl-ethyl)-phenoxy]-propionic acid ethyl ester 
• 5026-12-0 2-(2-hydroxyphenyl)-2,4,4-trimethylchroman 
• 63661-69-8 4'-hydroxy-2,4,4-trimethylflavan 
• 1608-68-0 2-isopropyl-phenyl acetate 
• 137408-17-4 2-(2-isopropenylphenoxy)propanoic acid 
• 137408-19-6 2-(2-Isopropenyl-phenoxy)-propionic acid ethyl ester 
• 10278-02-1 2-(2-methoxyphenyl)propene 
• 38865-54-2 <1-(2-Hydroxyphenyl)-1-methylethyl>-(2-isopropenylphenyl)-ether 
• 39477-82-2 2-(2-hydroxyphenyl)-2-methoxypropane 
• 1196734-02-7 C₁₂H₁₈O₃ 
• 1196734-03-8 C₂₀H₂₁NO₄ 
• 870553-71-2 C₁₁H₁₆O₃ 

Relevant articles and documents

Regioselective reductive openings of acetals; mechanistic details and synthesis of fluorescently labeled compounds

Regioselective reductive openings of mixed phenolic-benzylic acetals, using BH3·NMe3-AlCl3, was investigated, and a mechanism where the outcome is directed by the electrostatic potential of the two oxygen atoms is presente

Multicomponent Condensation Reactions via ortho-Quinone Methides

Iron(III) salts promote the condensation of aldehydes or acetals with electron-rich phenols to generate ortho-quinone methides that undergo Diels - Alder condensations with alkenes. The reaction sequence occurs in a single vessel to afford benzopyrans in up to 95% yield. The reaction was discovered while investigating a two-component strategy using 2-(hydroxy(phenyl)methyl)phenols to access the desired ortho-quinone methide in a Diels - Alder condensation. The two-component condensation also afforded the corresponding benzopyran products in yields up to 97%. Taken together, the two- and three-component strategies using ortho-quinone methide intermediates provide efficient access to benzopyrans in good yields and selectivities.

CYSTEINYL LEUKOTRIENE ANTAGONISTS

The present invention relates to novel cysteinyl leukotriene (specifically LTD4) antagonists, mainly to quinolin, quinoxaline or benz[c]thiazole derivatives represented by the general formula (I), or the pharmaceutically acceptable salt thereof, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders related to cysteinyl leukotriene, in mammals, more specially in humans.