30481-54-0

Basic information

• Product Name: 2-AMINO-5-NITROBENZANILIDE
• Synonyms: 2-Amino-5-nitro-N-phenylbenzamide;2-AMINO-5-NITROBENZANILIDE
• CAS NO: 30481-54-0
• Molecular Formula: C₁₃H₁₁N₃O₃
• Molecular Weight: 257.24
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 30481-54-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 202-204°C
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 6.15E-07mmHg at 25°C
• Refractive Index: 1.714
• PKA: 12.25±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-5-NITROBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-NITROBENZANILIDE(30481-54-0)
• EPA Substance Registry System: 2-AMINO-5-NITROBENZANILIDE(30481-54-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 30481-54-0(Hazardous Substances Data)

Usage

General Description

2-Amino-5-nitrobenzanilide is a chemical compound with the molecular formula C13H11N3O3. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and dyes. 2-Amino-5-nitrobenzanilide is known for its nitro and amino functional groups, which make it a versatile building block for the production of various organic compounds. It is also used in the manufacturing of hair dyes and other cosmetic products. Additionally, 2-Amino-5-nitrobenzanilide is used as a reagent in organic synthesis and as a research tool in chemical and biochemical studies. Due to its potential health hazards, proper handling and disposal procedures are necessary when working with this compound.

InChI:InChI=1/C13H11N3O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,14H2,(H,15,17)

Upstream product

• 62-53-3 aniline 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 69123-71-3 2-Amino-5-nitro-benzoyl chloride 
• 4693-02-1 6-nitroisatoic anhydride 

Downstream Products

• 60041-99-8 6-nitro-3-phenylbenzo[d][1,2,3]triazin-4(3H)-one 
• 1632062-57-7 2-(4-ethylpiperazin-1-yl)-6-nitro-3-phenylquinazolin-4(3H)-one 
• 21092-27-3 6-nitro-3-phenylquinazoline-2,4(1H,3H)-dione 
• 964-25-0 6-nitro-3-phenyl-4(3H)-quinazolinone 

Relevant articles and documents

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Opportunistic viruses are a major problem for immunosuppressed individuals, particularly following organ or stem cell transplantation. Current treatments are non-existent or suffer from problems such as high toxicity or development of resistant strains. We previously published that a trafficking inhibitor that targets a host protein greatly reduces the replication of human cytomegalovirus. This inhibitor was also shown to be moderately effective against polyomaviruses, another family of opportunistic viruses. We have developed a panel of analogues for this inhibitor and have shown that these analogues maintain their high efficacy against HCMV, while substantially lowering the concentration required to inhibit polyomavirus replication. By targeting a host protein these compounds are able to inhibit the replication of two very different viruses. These observations open up the possibility of pan-viral inhibitors for immunosuppressed individuals that are effective against multiple, diverse opportunistic viruses.

NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization.

NONTOXIC COMPOUNDS FOR THE TREATMENT AND PREVENTION OF HERPESVIRUS INFECTIONS

Compositions for preventing or treating virus infections inhibit the biogenesis of cytoplasmic viral assembly compartment (cVAC). The preferred compounds are dihydroquinazolinones.