30483-75-1 Usage
Description
N-(4-BROMOPHENYL)MORPHOLINE is an organic compound that serves as a crucial intermediate in the synthesis of various organic and pharmaceutical compounds. It is characterized by its unique molecular structure, which features a morpholine ring attached to a 4-bromophenyl group. This structure endows N-(4-BROMOPHENYL)MORPHOLINE with specific chemical properties that make it valuable in the development of new molecules and drugs.
Uses
Used in Organic Synthesis:
N-(4-BROMOPHENYL)MORPHOLINE is used as an organic synthesis intermediate for the creation of a wide range of chemical compounds. Its unique structure allows for various chemical reactions, such as substitution, addition, and condensation, which can lead to the formation of new molecules with diverse properties and applications.
Used in Pharmaceutical Industry:
N-(4-BROMOPHENYL)MORPHOLINE is used as a pharmaceutical intermediate in the development of new drugs. Its structural versatility and reactivity make it an ideal candidate for the synthesis of novel pharmaceutical compounds with potential therapeutic applications. N-(4-BROMOPHENYL)MORPHOLINE can be further modified and functionalized to create molecules with specific biological activities, targeting various diseases and medical conditions.
Used in Laboratory Research and Development:
N-(4-BROMOPHENYL)MORPHOLINE plays a significant role in laboratory research and development processes. It is often employed as a starting material or a key component in the synthesis of complex organic molecules, which can be used for various purposes, such as studying their chemical properties, evaluating their biological activities, or testing their potential applications in different fields.
Used in Chemical Production Process:
In the chemical production process, N-(4-BROMOPHENYL)MORPHOLINE is utilized as an intermediate to produce a variety of chemical products. Its presence in the synthesis pathway allows for the efficient and cost-effective production of target compounds, which can be further processed or formulated into final products for various applications, such as pharmaceuticals, agrochemicals, or specialty chemicals.
Synthesis
In an open flask, 10 mL of 1.5 M NaBr in pH 6.2 phosphate buffer (0.23 M in PO4) or pH 4.2 phosphate buffer (5% NaH2PO4) was added to a solution of 1 mmol of substrate dissolved in 9.75 mL of distilled 1,4- dioxane. To this mixture was added a freshly made solution of diphenyl ditelluride (1e, 0.25 mL of a 10 mM stock in 1,4-dioxane, 2.5 μmol, 0.25 mol % relative to substrate) followed by the addition of 8.8 M H2O2 according to Table 3. The reaction mixture was stirred at room temperature for the appropriate amount of time and was then diluted with 10 mL of water. The resulting solution was extracted with EtOAc (3 × 10 mL), and the combined organic extracts were washed with 0.5 M NaHSO3 (5 mL) and brine (10 mL), dried over MgSO4, and concentrated. Yields reported below are the mean of duplicate runs. N-(4-Bromophenyl)morpholine (21):28 product isolated as a tan solid (224 ± 1 mg, 93% yield). Mp 111-113 °C (lit.28 mp 111-112 °C).
Check Digit Verification of cas no
The CAS Registry Mumber 30483-75-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,4,8 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 30483-75:
(7*3)+(6*0)+(5*4)+(4*8)+(3*3)+(2*7)+(1*5)=101
101 % 10 = 1
So 30483-75-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H12BrNO/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8H2
30483-75-1Relevant articles and documents
The surprisingly facile formation of Pd(i)-phosphido complexes from: Ortho -biphenylphosphines and palladium acetate
Montgomery, Michelle,O'Brien, Harry M.,Méndez-Gálvez, Carolina,Bromfield, Caitlin R.,Roberts, Jack P. M.,Winnicka, Anna M.,Horner, Andrew,Elorriaga, David,Sparkes, Hazel A.,Bedford, Robin B.
, p. 3539 - 3542 (2019)
The widely-used ortho-biphenylphosphine ligands SPhos and RuPhos not only undergo facile orthometallation with palladium acetate, yielding strained, four-membered dimeric palladacycles but more surprisingly, in the presence of alcoholic solvents, along with the less encumbered analogue MePhos, yield unusual dinuclear Pd(i) complexes, in which the Pd-centers are bridged by both a phosphide ligand and by the arene of a coordinated phosphine donor.
Effect of Precatalyst Oxidation State in C-N Cross-Couplings with 2-Phosphinoimidazole-Derived Bimetallic Pd(I) and Pd(II) Complexes
Martinez, Erin E.,Moreno, Mariur Rodriguez,Barksdale, Caleb A.,Michaelis, David J.
supporting information, p. 2763 - 2767 (2021/08/27)
We report the catalytic activity of two phosphinoimidazole-derived bimetallic palladium complexes in Pd-catalyzed amination reactions. Our studies demonstrate that the starting oxidation state (Pd(I) or Pd(II)) of the dimeric complex has a significant effect on the efficiency of the catalytic reaction. The corresponding Pd(I) complex shows higher reactivity in Buchwald-Hartwig aminations, while the Pd(II) complex is much more reactive in carbonylative amination reactions. These new dimeric palladium complexes provide good to excellent reactivity and yields in the amination reactions tested.
Amination of Aryl Halides Mediated by Electrogenerated Nickel from Sacrificial Anode
Daili, Farah,Sengmany, Stéphane,Léonel, Eric
, p. 2462 - 2469 (2021/06/28)
Electrochemical C(sp2)?N couplings mediated by nickel salts generated from the sacrificial anode has been described for the first time. In this approach, the sacrificial nickel anode is employed as the sole source of nickel and the process, operationally simple to set up, enables the preparation of functionalized arylamine derivatives with moderate to good yields, under mild reaction conditions and without additional ligand. A cooperative process between the two electrodes is involved in the proposed mechanism.
