30511-21-8Relevant articles and documents
Organic synthesis by Twin Screw Extrusion (TSE): Continuous, scalable and solvent-free
Crawford, Deborah E.,Miskimmin, Clodagh K. G.,Albadarin, Ahmad B.,Walker, Gavin,James, Stuart L.
supporting information, p. 1507 - 1518 (2017/05/10)
Mechanochemistry provides a method to reduce or eliminate the use of solvents by carrying out reactions through the grinding of neat reagents. Until recently a significant drawback of this form of synthesis has been the limited ability to scale up. Howeve
Expeditious reaction of ninhydrin with active methylene compounds on montmorillonite K10 clay
Chakrabarty, Manas,Mukherji, Ajanta,Arima, Shiho,Harigaya, Yoshihiro,Pilet, Guillaume
experimental part, p. 189 - 197 (2010/03/26)
Ninhydrin reacted expeditiously with thirteen active methylene compounds on montmorillonite K10 clay at room temperature to furnish, in 5 min, a Knoevenagel condensate in one case, aldols in six cases, aldol-derived cyclic hemiketals in three cases, and interesting products in the remaining three cases. Almost identical results were obtained, but faster, when the reactions were carried out in water on steam-bath. The structures of two novel products were also confirmed by single-crystal X-ray diffraction analysis. Graphical abstract: [Figure not available: see fulltext.]
Quantitative reaction cascades of ninhydrin in the solid state
Kaupp, Gerd,Naimi-Jamal, M. Reza,Schmeyers, Jens
, p. 594 - 600 (2007/10/03)
Crystalline ninhydrin (1) undergoes waste-free solid-state cascade reactions with dimedone, L-proline, three o-phenylenediamines, o-mercaptoaniline, two ureas, three thioureas, and methyl 3-aminocrotonate. The yields are quantitative and give pure crystal
