30557-06-3

Basic information

• Product Name: 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
• Synonyms: 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;5-Methoxy-3,4-dihydroquinolin-2(1H)-one;3,4-dihydro-5-Methoxy-2(1H)-Quinolinone;2(1H)-quinolinone, 3,4-dihydro-5-methoxy-
• CAS NO: 30557-06-3
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.2
• Mol File: 30557-06-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 175-177 °C(Solv: methanol (67-56-1))
• Boiling Point: 370.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.159±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.37±0.20(Predicted)
• CAS DataBase Reference: 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(30557-06-3)
• EPA Substance Registry System: 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(30557-06-3)

Safety Data

• Hazardous Substances Data: 30557-06-3(Hazardous Substances Data)

Usage

General Description

5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE is a chemical compound with the molecular formula C10H11NO2. It is a heterocyclic compound belonging to the quinolin-2-one family, with a methoxy group (CH3O) attached to the 5th position of the quinoline ring. 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE has potential use in medicinal chemistry, with reported properties including antipsychotic, anxiolytic, and sedative effects. It may also have potential as a therapeutic agent for treating neurological and psychiatric disorders. The chemical structure and properties of 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE make it a potentially important compound for further research and development in the field of pharmaceuticals.

Upstream product

• 82673-72-1 2'-ethoxycarbonylethyl-3'-methoxy-2,2-dimethylpropionanilide 
• 536-90-3 m-Anisidine 
• 82673-65-2 N-(2-formyl-3-methoxyphenyl)pivalamide 
• 82673-71-0 ethyl (2-methoxy-6-pivaloylamino)cinnamate 
• 6342-77-4 2-methoxy-benzenepropanoic acid 

Downstream Products

• 145969-30-8 1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-methoxy-3,4-dihydro-2-quinolinone 
• 145969-84-2 5-methoxy-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril 
• 30389-33-4 5-hydroxycarbostyril 
• 160893-04-9 5-methoxy-2(1H)-quinolinone 

Relevant articles and documents

Room Temperature Benzofused Lactam Synthesis Enabled by Cobalt(III)-Catalyzed C(sp2)?H Amidation

Benzofused lactams, especially indolin-2-one and dihydroquinolin-2-one are popular structural motives in durgs and natural products. Herein, we developed a room temperature and robust synthesis of benzofused lactams through cobalt(III)-catalyzed C(sp

PYRIMIDINE COMPOUNDS AND USE THEREOF

The invention relates to novel pyrimidine compounds of general formula (I), in which: A represents a group C=W or CRfRg; B represents a chemical bond or a group CRhRi; X represents O, S, a group N-Rk or a group CRmRn; D represents C=O or a chemical bond; E represents a linear or branched 2- to 10-membered alkylene chain that, as members of a chain, can have 1 or 2 non-adjacent heteroatom group(s) K, which is selected among O, S, S(O), S(O)2 and N-Rp and which can comprise a carbonyl group and/or a cycloalkanediyl group and/or a double or triple bond; W represents oxygen or sulfur; Z, together with the carbon atoms, to which it is bound, represents a condensed, optionally substituted 5-, 6- or 7-membered carbocyclic compound or heterocyclic compound that has 1, 2, 3 or 4 heteroatoms, which are selected among N, O and S; J represents CH2, CH2-CH2 or CH2-CH2-CH2; M represents CH or N; Y represents CH2, CH2-CH2 or CH2-CH2-CH2 or M-X, together, represent CH=C or CH2-CH=C; n is 0 or 1, and; Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rk, Rp, R1, R2, R3, R4, R5 and R6 have the meanings cited in the claims and in the description. The invention also relates to the physiologically compatible acid addition salts of the aforementioned compounds, and to the use of these compounds of general formula (I) and of the physiologically compatible acid addition salts of compounds (I) for producing a pharmaceutical agent for treating diseases, which respond to the influence of dopamine D3 receptor antagonists or agonists.

Synthetic Application of Lithiation Reactions: A Convenient Synthesis of 3,4-Dihydro-5-hydroxycarbostyril, 1,2,3,4-Tetrahydro-5-hydroxy-2-oxo-1,7-naphthyridine, and Methyl 3-Methoxypyridine-4-carboxylate

3,4-Dihydro-5-hydroxycarbostyril (3), a key intermediate for a clinically used β-receptor blocking agent (1), and its 7-aza analog (4) were prepared by an acid-catalyzed cyclization of the N-pivaloylamino-esters (17 and 19), which were obtained by using o