30568-32-2

Basic information

• Product Name: 2-(4-chlorophenyl)-2-methylpropanenitrile
• Synonyms: 2-(4-chlorophenyl)-2-methylpropanenitrile;2-(4-CHLOROPHENYL)-2-METHYLPROPIONITRILE
• CAS NO: 30568-32-2
• Molecular Formula: C₁₀H₁₀ClN
• Molecular Weight: 179.6461
• Mol File: 30568-32-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 122-127 °C(Press: 7 Torr)
• Appearance: /
• Density: 1.112±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-chlorophenyl)-2-methylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-2-methylpropanenitrile(30568-32-2)
• EPA Substance Registry System: 2-(4-chlorophenyl)-2-methylpropanenitrile(30568-32-2)

Safety Data

• Hazardous Substances Data: 30568-32-2(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Odor

Pungent

Usage

Production of pharmaceuticals and agrochemicals

Hazard classification

Hazardous substance

Health risks

Skin irritation; respiratory issues

Proper handling and storage

Essential to prevent exposure and minimize risks to human health and the environment

Upstream product

• 74-88-4 methyl iodide 
• 140-53-4 p-chlorobenzyl cyanide 
• 149-73-5 trimethyl orthoformate 
• 78-82-0 Isobutyronitrile 
• 352-33-0 1-Chloro-4-fluorobenzene 

Downstream Products

• 30568-38-8 2-(4-chloro-phenyl)-2-methyl-propionic acid amide 
• 16703-39-2 3-(4-chlorophenyl)-3-methylbutan-2-one 
• 6258-30-6 2-(4-chlorophenyl)-2-methylpropanoic acid 
• 20401-29-0 α,α-dimethyl-(4-chlorophenyl)acetaldehyde 
• 42299-95-6 2-(4-chlorophenyl)-2-methyl-propan-1-amine 
• 106897-77-2 1-chloro-4-(1,1-dimethyl-2-propenyl)benzene 
• 106897-80-7 2-<(4-(1,1-dimethyl-2-propenyl)phenyl)>propionic acid 
• 106897-72-7 ethyl 2-<(4-(1,1-dimethyl-2-propenyl)phenyl)>propionate 
• 106897-69-2 C₁₈H₂₁ClN₂O₂S 
• 101104-04-5 2-(4-chloro-phenyl)-2-methyl-propionic acid cyclopentyl ester 
• 100845-90-7 1-carboxaldehyde-1-(p-chlorophenyl)-cyclopropane 
• 5558-63-4 2-benzyl-2-phenyl-butyronitrile 
• 6269-30-3 4-(4-chlorophenyl)-4-methylpentan-2-one 
• 848846-58-2 2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid 

Relevant articles and documents

Cobalt-catalyzed C[sbnd]H activation/C[sbnd]O formation: Synthesis of benzofuranones

Herein, C[sbnd]H activation/C[sbnd]O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is efficient and low-cost method to synthesized benzofuranones from α,α-disubstitution acetic acid.

C-3 NOVEL TRITERPENONE WITH C-28 UREA DERIVATIVES AS HIV INHIBITORS

The present invention relates to C-3 novel triterpenone with C-28 urea derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, W, J and X are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.

Palladium(II)-catalyzed directed trifluoromethylthiolation of unactivated C(sp3)-H bonds

The synthesis of trifluoromethylthiolated aliphatic acid derivatives by Pd-catalyzed C(sp3)-H bond functionalization was developed. Using a bidentate directing group, the direct and selective introduction of a SCF3 moiety was possible on a range of amides with remarkable selectivity for C(sp3)-centers with an electrophilic SCF3 source and pivalic acid as an additive. This work constitutes an example of the unactivated C(sp3)-SCF3 bond formation by C-H activation offering a new access to relevant molecules.