30577-83-4

Basic information

• Product Name: N,N-dimethyl-2,3-dimethoxybenzamide
• CAS NO: 30577-83-4
• Molecular Weight: 209.245
• Mol File: 30577-83-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-2,3-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2,3-dimethoxybenzamide(30577-83-4)
• EPA Substance Registry System: N,N-dimethyl-2,3-dimethoxybenzamide(30577-83-4)

Safety Data

• Hazardous Substances Data: 30577-83-4(Hazardous Substances Data)

Upstream product

• 1521-38-6 2,3-dimethoxybenzoic acid 
• 124-40-3 dimethyl amine 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 

Relevant articles and documents

Beyond directed ortho metalation: Ru-catalyzed CAr-O activation/cross-coupling reaction by amide chelation

Disclosed is a new, catalytic, and general methodology for the chemical synthesis of biaryl, heterobiaryl, and polyaryl molecules by the cross-coupling of o-methoxybenzamides with aryl boroneopentylates. The reaction is based on the activation of the unreactive C-OMe bond by the proximate amide directing group using catalytic RuH2(CO)(PPh3)3 conditions. A one-step, base-free coupling process is thereby established that has the potential to supersede the useful two-step directed ortho metalation/cross- coupling reaction involving cryogenic temperature and strong base conditions. High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, minimum waste, and convenient scale-up make these reactions suitable for industrial applications.