30577-84-5

Basic information

• Product Name: N,N-diethyl-2,3-dimethoxybenzamide
• CAS NO: 30577-84-5
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.2949
• Mol File: 30577-84-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 380.2°C at 760 mmHg
• Flash Point: 183.7°C
• Density: 1.051g/cm³
• Vapor Pressure: 5.54E-06mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: N,N-diethyl-2,3-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2,3-dimethoxybenzamide(30577-84-5)
• EPA Substance Registry System: N,N-diethyl-2,3-dimethoxybenzamide(30577-84-5)

Safety Data

• Hazardous Substances Data: 30577-84-5(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 85630-19-9 N,N-diethyl-1-carbamyloxy-2-methoxybenzene 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 90-05-1 2-methoxy-phenol 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 101270-37-5 O-(2-N,N-diethylcarbamoyloxy)phenyl N,N-diethylcarbamate 
• 74-88-4 methyl iodide 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 70946-05-3 N,N-diethyl 2,3-dimethoxy-6-trimethylsilylbenzamide 
• 70946-03-1 N,N-diethyl-2,3-dimethoxy-6-(3,4-methylenedioxyphenylhydroxylmethyl)benzamide 
• 70946-00-8 N,N-diethyl 2-carboxy-5,6-dimethoxybenzamide 
• 70946-06-4 N,N-diethyl 2-iodo-5,6-dimethoxy-benzamide 
• 70946-04-2 N,N-diethyl-2,3-dimethoxy-6-(N-phenylcarbamoyl)benzamide 
• 70946-01-9 2,3-Dimethoxy-6-formylbenzoesaeure-(N,N-diethyl)-amid 
• 70946-02-0 ethyl 3,4-dimethoxy-2-(N,N-diethylcarbamoyl)benzoylformate 
• 70945-99-2 N,N-diethyl-2,3-dimethoxy-6-methyl-benzamide 
• 596805-21-9 N,N-diethyl-2-methylsulfanyl-5,6-dimethoxybenzamide 
• 530101-33-8 N,N-diethyl-2,3-dimethoxy-6-allylbenzamide 
• 500732-59-2 7-benzyl-1,2-dimethoxy-xanthen-9-one 
• 500732-60-5 6-(4-benzyl-phenoxy)-N,N-diethyl-2,3-dimethoxy-benzamide 
• 569-31-3 meconin 
• 518-90-1 3,4-dimethoxy-phthalic acid 

Relevant articles and documents

Directed ortho-Metalation of Aryl Amides, O-Carbamates, and Methoxymethoxy Systems: Directed Metalation Group Competition and Cooperation

A systematic study on the competitive metalation of derivatives containing four directed metalation groups (DMGs), namely, Cl, OMe, methoxymethoxy (OMOM), and CONEt2, in comparison with the OCONEt2 DMG is described. In addition, the

Anti-tumoral activities of dioncoquinones B and C and related naphthoquinones gained from total synthesis or isolation from plants

Dioncoquinones belong to a family of natural naphthoquinone products of interest due to their promising anti-tumoral and anti-infective activities. In particular, dioncoquinones A (5) and B (6) have been shown to be highly active against Leishmania major and multiple myeloma cells without any significant toxicity toward normal blood cells. Their effective concentrations against multiple myeloma cell lines were similar to those of melphalan, a well known DNA-alkylating agent used in a standard therapy against B cell lymphoma and multiple myeloma. We report on the first total synthesis of the highly oxygenated anti-tumoral agent dioncoquinone B (6) and the isolation of its new, even higher-oxygenated analogs, dioncoquinones C (7), D (8), and E (9), from cell cultures of Triphyophyllum peltatum. In addition, several derivatives of these compounds were synthesized, including dioncoquinone C (7), and a small library of naphthoquinones was created. Furthermore, the first structure-activity relationship (SAR) study on this class of compounds was conducted, showing that each of the three hydroxy groups, at C-3, C-5, and C-6, is required for improved anti-tumoral activities and decreased cytotoxicities.

Application of directed metallation in synthesis. Part 3: Studies in the synthesis of (±)-semivioxanthin and its analogues

The synthesis of several analogues of (±)-semivioxanthin including five thiophene analogues, using directed metalation are reported. The strategy consisted of the synthesis of functionalized naphthalene or benzo[b]thiophene as building blocks followed by