30672-70-9 Usage
General Description
2-fluorosulphonylbenzenesulphonyl chloride is a chemical compound that consists of a benzene ring with two sulphonyl chloride groups and a fluorine atom attached. It is a highly reactive and corrosive compound that is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is an important building block in organic chemistry, as it can be used to introduce sulfonyl fluoride groups into various organic molecules. 2-fluorosulphonylbenzenesulphonyl chloride is also used as a reagent in organic synthesis and as a precursor to other important chemicals. Due to its reactivity and corrosiveness, it must be handled with extreme care and proper safety precautions in a controlled laboratory environment.
Check Digit Verification of cas no
The CAS Registry Mumber 30672-70-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,6,7 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 30672-70:
(7*3)+(6*0)+(5*6)+(4*7)+(3*2)+(2*7)+(1*0)=99
99 % 10 = 9
So 30672-70-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClFO4S2/c7-13(9,10)5-3-1-2-4-6(5)14(8,11)12/h1-4H
30672-70-9Relevant articles and documents
(Chlorosulfonyl)benzenesulfonyl Fluorides - Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
Tolmachova, Kateryna A.,Moroz, Yurii S.,Konovets, Angelika,Platonov, Maxim O.,Vasylchenko, Oleksandr V.,Borysko, Petro,Zozulya, Sergey,Gryniukova, Anastasia,Bogolubsky, Andrey V.,Pipko, Sergey,Mykhailiuk, Pavel K.,Brovarets, Volodymyr S.,Grygorenko, Oleksandr O.
, p. 672 - 680 (2018/11/23)
Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor.