30687-03-7Relevant articles and documents
N-vinyl amide and preparation method thereof
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Paragraph 0013; 0014; 0015, (2019/12/25)
The invention relates to N-vinyl amide and a preparation method thereof. The preparation method comprises the following concrete steps: in the presence of triethylamine, reacting acyl chloride with 2-chloroethylamine hydrochloride to obtain corresponding N-(2-chloroethyl)amide, treating the N-(2-chloroethyl)amide with lithium diisopropylamide at room temperature, then adding halogenated hydrocarbon, carrying out a stirring reaction at room temperature for 4 hours, removing the solvent, and performing purification to obtain an N-vinyl amide compound. The preparation method of the invention is simple in synthetic route and uses easily-available raw materials; and the prepared N-vinyl amide compound is a good synthetic intermediate, and has potential biological activity and good application value.
Structural Revision and Synthesis of Sinharine and Methylsinharine
Johnson, Wynona M.,Littler, Stuart W.,Strauss, Christopher R.
, p. 751 - 756 (2007/10/02)
An unambiguous synthesis of the published structure for the natural product sinharine (1) showed that the assignment was incorrect. (E)-3-(Methylthio)-N-(2-phenylethyl)propenamide (4) was proposed as an alternative structure and this was confirmed by synt
