306935-41-1 Usage
Description
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID, also known as IPBT-5CA (306935-41-1), is a chemical compound that functions as a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). It exhibits no activity at the closely related high-affinity niacin receptor GPR109a, making it a potentially valuable compound for specific applications in the pharmaceutical and biotechnology industries.
Uses
Used in Pharmaceutical Research:
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID is used as a research compound for studying the role and function of the GPR109b receptor in various biological processes. Its high selectivity for GPR109b makes it a valuable tool in understanding the receptor's involvement in different pathways and its potential as a therapeutic target.
Used in Drug Development:
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID is used as a lead compound in the development of new drugs targeting the GPR109b receptor. Its selectivity for this receptor may lead to the creation of novel therapeutics for conditions where GPR109b plays a significant role, such as certain metabolic disorders or inflammatory diseases.
Used in Biotechnology Applications:
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID is used as a molecular probe in biotechnology to investigate the interactions between GPR109b and other proteins or molecules. This can help in identifying potential drug targets or designing new molecules with improved selectivity and efficacy.
Used in Diagnostics:
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID can be used as a diagnostic agent to detect the presence or activity of the GPR109b receptor in biological samples. This may be particularly useful in the context of disease diagnosis or monitoring treatment response in patients.
Biological Activity
Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.
References
1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227
Check Digit Verification of cas no
The CAS Registry Mumber 306935-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,6,9,3 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 306935-41:
(8*3)+(7*0)+(6*6)+(5*9)+(4*3)+(3*5)+(2*4)+(1*1)=141
141 % 10 = 1
So 306935-41-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15)
306935-41-1Relevant articles and documents
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
Semple, Graeme,Skinner, Philip J.,Cherrier, Martin C.,Webb, Peter J.,Sage, Carleton R.,Tamura, Susan Y.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.
, p. 1227 - 1230 (2007/10/03)
1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-raising drug niacin. N
