306937-25-7 Usage
General Description
4,6-Dichloro-1H-indole-2-carbonyl chloride is a chemical compound with the molecular formula C10H5Cl3N2O. It is a derivative of indole and is commonly used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. The compound is a reactive and versatile intermediate, often used in the synthesis of indole-based compounds. It is a light yellow solid that is sensitive to moisture and should be handled and stored with caution. 4,6-Dichloro-1H-indole-2-carbonyl chloride is a valuable compound in the field of medicinal chemistry and is known for its use in the development of novel drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 306937-25-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,6,9,3 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 306937-25:
(8*3)+(7*0)+(6*6)+(5*9)+(4*3)+(3*7)+(2*2)+(1*5)=147
147 % 10 = 7
So 306937-25-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H4Cl3NO/c10-4-1-6(11)5-3-8(9(12)14)13-7(5)2-4/h1-3,13H
306937-25-7Relevant articles and documents
Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity
Jansen, Michaela,Dannhardt, Gerd
, p. 855 - 865 (2007/10/03)
The synthetic procedures to obtain indole derivatives with different acidic functions at position 2 of the indole are reported. The synthesised and tested derivatives comprise 5-tetrazolyl, 1,3,4-oxadiazol-5-yl-2-one, and indole-2-carboxylic acid amides with 5-aminotetrazole, methanesulphonamide and trifluoromethanesulphonamide moieties. The binding affinity was evaluated using [3H]MDL 105,519 and pig cortical brain membranes. In general, compounds with acidic functions different from a carboxylic acid moiety are less potent than indole-2-carboxylic acid derivatives. Also, the 4,6-dichloro substitution pattern was compared to 5-tert-butyl derivatives and compounds not substituted in the benzene moiety of the indole, indicating that the affinity increases from 5-tert-butyl over unsubstituted to 4,6-dichloro substituted derivatives.
C:Corrosive;
