30710-21-5

Basic information

• Product Name: (6-NITROBENZOTHIAZOL-2-YL)-HYDRAZINE
• Synonyms: 2-HYDRAZINO-6-NITRO-1,3-BENZOTHIAZOLE;1-(6-NITROBENZO[D]THIAZOL-2-YL)HYDRAZINE;(6-NITROBENZOTHIAZOL-2-YL)-HYDRAZINE;2(3H)-Benzothiazolone,6-nitro-,hydrazone(9CI);2-HYDRAZINYL-6-NITROBENZO[D]THIAZOLE
• CAS NO: 30710-21-5
• Molecular Formula: C₇H₆N₄O₂S
• Molecular Weight: 210.21
• Product Categories: BENZOTHIAZOLE
• Mol File: 30710-21-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 273-274°C
• Boiling Point: 425.2°C at 760 mmHg
• Flash Point: 211°C
• Appearance: /
• Density: 1.685g/cm³
• Vapor Pressure: 1.94E-07mmHg at 25°C
• Refractive Index: 1.848
• PKA: -0.17±0.20(Predicted)
• CAS DataBase Reference: (6-NITROBENZOTHIAZOL-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (6-NITROBENZOTHIAZOL-2-YL)-HYDRAZINE(30710-21-5)
• EPA Substance Registry System: (6-NITROBENZOTHIAZOL-2-YL)-HYDRAZINE(30710-21-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 30710-21-5(Hazardous Substances Data)

Usage

General Description

(6-Nitrobenzothiazol-2-yl)-hydrazine is a chemical compound with the molecular formula C7H5N5OS. It is a yellow to orange powder that is primarily used as a reagent in organic synthesis. It is known for its strong reducing properties and is often used in the preparation of various pharmaceuticals and agrochemicals. Additionally, it has shown potential as an anti-cancer agent in various studies. (6-NITROBENZOTHIAZOL-2-YL)-HYDRAZINE is considered to be stable under normal conditions, but it should be handled with care due to its potential reactivity and toxicity. Overall, (6-nitrobenzothiazol-2-yl)-hydrazine is a versatile compound with various potential applications in the field of chemistry and medicine.

InChI:InChI=1/C7H6N4O2S/c8-10-7-9-5-2-1-4(11(12)13)3-6(5)14-7/h1-3H,8H2,(H,9,10)

Upstream product

• 2407-11-6 2-chloro-6-nitrobenzothiazole 
• 4308-10-5 2-methoxy-6-nitrobenzo[d]thiazole 
• 70292-59-0 2-isopropoxy-6-nitrobenzo[d]thiazole 
• 6285-57-0 2-amino-6-nitrobenzothiazole 
• 100-01-6 4-nitro-aniline 
• 3696-22-8 p-nitrophenylthiourea 

Downstream Products

• 6796-83-4 5-(2,4-dinitro-anilino)-penta-2,4-dienal (6-nitro-benzothiazol-2-yl)-hydrazone 
• 68775-27-9 2-(6-nitro-benzothiazol-2-yl)-5-p-tolyl-2H-pyrazol-3-ylamine 
• 68775-28-0 5-(4-chloro-phenyl)-2-(6-nitro-benzothiazol-2-yl)-2H-pyrazol-3-ylamine 
• 90220-89-6 <6-Nitro-benzthiazolon>--azin 
• 78364-42-8 2-(4-Isopropyl-3,5-dimethyl-pyrazol-1-yl)-6-nitro-benzothiazole 
• 2407-11-6 2-chloro-6-nitrobenzothiazole 
• 939795-77-4 C₂₁H₂₂N₄O₄S 
• 939795-78-5 C₂₀H₂₀N₄O₄S 
• 659743-01-8 N₂-(1-benzylpiperidin-4-yl)benzothiazole-2,6-diamine 
• 939795-84-3 C₁₉H₂₁N₄SF 
• 659743-39-2 N₂-[2-(4-bromophenyl)ethyl]benzothiazol-2,6-diamine 
• 939795-85-4 C₂₀H₂₄N₄OS 
• 939795-86-5 C₂₀H₂₄N₄OS 
• 939795-87-6 C₂₁H₂₄N₄O₂S 

Relevant articles and documents

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NOVEL BENZOTHIAZOLE DERIVATIVES WITH ENHANCED BIOLOGICAL ACTIVITY

The present invention discloses novel conjugates of benzothiazole derivatives with cystine and glucosamine and their method of synthesis. Their method of synthesis is easy and eco-friendly, avoiding the use of hazardous materials or reactions, The compounds offer technical advantages of increased solubility, potency, selectivity and biological activity. The novel compounds show antibacterial, antifungal and anticancer activities. Formula, physico-chemical data and biological activity of the novel derivatives are as given in Tables 1 to 9.

Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents

A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00 μg/ml) against Mycobacterium tuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC 3.0 μg/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene) hydrazinyl) benzothiazole showed MIC of 1.5 μg/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs.