30727-29-8

Basic information

• Product Name: 2-(dimethylamino)cyclohexan-1-ol
• Synonyms: 2-(dimethylamino)cyclohexan-1-ol;Einecs 250-313-3;Cyclohexanol, 2-(diMethylaMino)-
• CAS NO: 30727-29-8
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.22668
• EINECS: 250-313-3
• Mol File: 30727-29-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 216.4°Cat760mmHg
• Flash Point: 86.1°C
• Appearance: /
• Density: 0.97g/cm³
• PKA: 14.94±0.40(Predicted)
• CAS DataBase Reference: 2-(dimethylamino)cyclohexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(dimethylamino)cyclohexan-1-ol(30727-29-8)
• EPA Substance Registry System: 2-(dimethylamino)cyclohexan-1-ol(30727-29-8)

Safety Data

• Hazardous Substances Data: 30727-29-8(Hazardous Substances Data)

Usage

General Description

2-(dimethylamino)cyclohexan-1-ol, also known as DMAC, is a chemical compound with the molecular formula C9H19NO. It is a tertiary amine and an alcohol, with a cyclohexane ring and a dimethylamino functional group. DMAC is commonly used as a solvent in various industries, including pharmaceuticals, dyes, and polymers. It is also used in organic reactions as a mild base and as a chiral auxiliary. DMAC has a boiling point of 161-163 °C and a melting point of -5 °C, and is a clear, colorless liquid with a characteristic amine odor. It is important to handle DMAC with caution, as exposure to high concentrations can cause irritation to the skin, eyes, and respiratory tract.

InChI:InChI=1/C8H17NO/c1-9(2)7-5-3-4-6-8(7)10/h7-8,10H,3-6H2,1-2H3

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 124-40-3 dimethyl amine 
• 6970-60-1 2-N,N-dimethylaminocyclohexanone 
• 1056477-06-5 2-bromocyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 4065-80-9 2-methylenecyclohexanol 
• 67198-21-4 (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane 
• 67198-26-9 trans-N,N-dimethyl-N-methyl-1,2-cyclohexanediamine 
• 67198-27-0 trans-N-<2-(dimethylamino)cyclohexyl>formamide 
• 67197-92-6 2-(3,4-Dichloro-phenyl)-N-((1S,2S)-2-dimethylamino-cyclohexyl)-N-methyl-acetamide 

Relevant articles and documents

Calcium trifluoroacetate as an efficient catalyst for ring-opening of epoxides by amines under solvent-free conditions

Ca(CF3CO2)2 efficiently catalyzed the selective ring-opening of epoxides by amines leading to the synthesis of β-aminoalcohols. The reaction works well with various aromatic and aliphatic amines under solvent-free conditions. Corresponding β-aminoalcohols were obtained in excellent yields with high regioselectivity. The catalyst was easily prepared by reaction of CaH 2 in trifluoroacetic acid.

Stereoselective Method for the Production of Clopidogrel

The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.

Structural characterization of two novel potential anticholinesterasic agents

Two novel compounds with possible anticholinesterase activity have been synthesized containing a carbamate and a dimethylamine group in 1,2-positions of a cyclohexane ring (cis and trans isomers). Conformer populations were established by a combination of NMR 1H coupling constant analysis and DFT (B3LYP/6-311 + G(d,p)) calculations. 13C chemical shifts were calculated in order to confirm signal attributions. The cis isomer adopts a conformation in which the carbamate group lies at the axial position (>99%), whereas the trans isomer adopts a diequatorial arrangement (98%). These preferences have been explained in terms of syn-1,3-diaxial interactions of the individual groups.