307335-41-7

Basic information

• Product Name: 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester
• CAS NO: 307335-41-7
• Molecular Weight: 368.86
• Mol File: 307335-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester(307335-41-7)
• EPA Substance Registry System: 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester(307335-41-7)

Safety Data

• Hazardous Substances Data: 307335-41-7(Hazardous Substances Data)

Upstream product

• 23145-88-2 1-[(4-chlorophenyl)methyl]piperazine 
• 685-87-0 Diethyl 2-bromomalonate 

Downstream Products

• 307335-44-0 2-(2-amino-benzyl)-2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester 
• 307335-45-1 3-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid ethyl ester 
• 307335-47-3 3-[4-(4-chloro-benzyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one 
• 307335-43-9 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester 

Relevant articles and documents

Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: A novel series of mixed dopamine D2/D4 receptor antagonists

3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (δ-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (γ-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones (ε-lactams) were also prepared and examined. (C) 2000 Elsevier Science Ltd.