30752-23-9

Basic information

• Product Name: 1-Bromo-4-isobutoxybenzene
• Synonyms: 1-Bromo-4-isobutoxybenzene
• CAS NO: 30752-23-9
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.11362
• Mol File: 30752-23-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 257.538°C at 760 mmHg
• Flash Point: 112.634°C
• Appearance: /
• Density: 1.276g/cm³
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 1-Bromo-4-isobutoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-isobutoxybenzene(30752-23-9)
• EPA Substance Registry System: 1-Bromo-4-isobutoxybenzene(30752-23-9)

Safety Data

• Hazardous Substances Data: 30752-23-9(Hazardous Substances Data)

Usage

Physical state

Colorless to light yellow liquid

Usage

a. Organic synthesis
b. Intermediate for pharmaceuticals and agrochemicals production
c. Reactant in the manufacture of other organic compounds (pharmaceuticals and pesticides)
d. Solvent in various chemical processes

Safety precautions

a. Harmful if swallowed
b. Harmful if inhaled
c. Harmful if in contact with skin
d. Proper safety measures should be followed when handling

InChI:InChI=1/C10H13BrO/c1-8(2)7-12-10-5-3-9(11)4-6-10/h3-6,8H,7H2,1-2H3

Upstream product

• 1126-75-6 (isobutyloxy)benzene 
• 106-41-2 4-bromo-phenol 
• 513-38-2 Isobutyl iodide 
• 78-77-3 Isobutyl bromide 
• 78-83-1 2-methyl-propan-1-ol 

Downstream Products

• 153624-44-3 para-isobutoxyphenylboronic acid 
• 1369026-19-6 C₁₄H₁₇N₃O₂ 
• 1421597-99-0 C₁₆H₂₅BO₃ 
• 1139901-88-4 tert-butyl 2-(3’-cyano-4’-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 
• 144060-53-7 febuxostat 
• 876918-26-2 5-bromo-2-isobutoxy-benzonitrile 
• 30762-00-6 4-isobutoxybenzoic acid 
• 1428418-60-3 4,7-bis(4-isobutoxyphenyl)-2-isobutyl-2H-benzo[d][1,2,3]triazole 

Relevant articles and documents

Alkyl chain-functionalized hole-transporting domains in zinc(II) dye-sensitized solar cells

FTO/TiO2 electrodes have been functionalized with {Zn(tpyanchor)(tpyancillary)}2+ dyes (tpy = 2,2′:6′,2″-terpyridine) using a stepwise method to sequentially introduce (i) the anchoring ligand tpyanchor (either a dicarboxylic acid or a diphosphonic acid), (ii) Zn2+ ions, and (iii) chromophoric ancillary (4-([2,2′:6′,2″-terpyridin]-4′-yl)-N,N-bis(4-alkoxyphenyl)aniline ligands. A comparison of unmasked and fully masked DSSCs containing representative dyes shows a significant drop in photon-to-current efficiency upon masking. Solid-state absorption spectra of the dye-functionalized electrodes confirm that the intensity of absorption decreases with the steric demands of the ancillary ligand. DSSC measurements show that the {Zn(tpyanchor)(tpyancillary)}2+ dyes give poor photon-to-current efficiencies, values of the short circuit current density (JSC) and the external quantum efficiency (EQE) spectra are consistent with very poor electron injection. Introducing longer alkoxy chains in place of methoxy substituents in the hole-transporting domains in tpyancillary is beneficial, resulting in increased JSC and VOC, although values remain low despite the 'push-pull' design of the sensitizers.

ACYL SULFONAMIDE NaV1.7 INHIBITORS

The present disclosure relates to compounds of formula I which inhibit NaV1.7, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

Facile one-pot transformation of arenes into aromatic nitriles under metal-cyanide-free conditions

Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were treated with dichloromethyl methyl ether and ZnBr2, and then with molecular iodine and aq. ammonia to give the corresponding aromatic nitriles in good yields. Using this method, febuxostat was efficiently prepared from 4-bromophenol in four steps. The method can be used for the preparation of aromatic nitriles from arenes in one pot under metal-cyanide-free conditions. Various electron-rich arenes could be effectively converted into the corresponding aromatic nitriles in good yields, by treatment with ZnBr2 and dichloromethyl methyl ether, followed by reaction with molecular iodine and aq. ammonia.