307557-48-8

Basic information

• Product Name: 2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE
• Synonyms: 2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE
• CAS NO: 307557-48-8
• Molecular Formula: C14H4Cl4F2N2O
• Molecular Weight: 396
• Mol File: 307557-48-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 489.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.613±0.06 g/cm3(Predicted)
• PKA: -7.63±0.50(Predicted)
• CAS DataBase Reference: 2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE(307557-48-8)
• EPA Substance Registry System: 2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE(307557-48-8)

Safety Data

• Hazardous Substances Data: 307557-48-8(Hazardous Substances Data)

Usage

General Description

2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole is an organic compound with the chemical formula C12H4Cl4F2N2O. It is a white crystalline solid that is used in the synthesis of various pharmaceuticals and agrochemicals. This chemical has potential applications as a building block in the development of new drugs due to its unique structure and properties. It is important to handle this compound with caution, as it may have toxic or harmful effects if improperly managed.

Upstream product

• 86522-89-6 2,4-dichloro-5-fluoro-benzoic acid 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 

Relevant articles and documents

Synthesis of some new fluorine containing 1,3,4-oxadiazole derivatives as potential antibacterial and anticancer agents

The synthesis of a number of 1,3,4-oxadiazole derivatives have been described. 2,4-Dichloro-5-fluorobenzoyl hydrazine 1 on reacting with aromatic acids in presence of phosphorus oxychloride affords 2,5-disubstituted-1,3,4- oxadiazoles 2a-j. Aroyl hydrazine on reacting with carbon disulphide under basic condition gives oxadiazol-2-thione 3. Oxadiazol-2-thiones are regioselectively aminomethylated to give N-aminomethylated products 4a-c. Further, 3 undergoes regioselective alkylation on treating with alkyl/aroyl halides to give S-alkyl/aroyl products 5a-c. All the newly synthesized compounds have been screened for their antibacterial activity. Most of them show promising antibacterial activity. Also two out of nine compounds show anticancer activity in the primary anticancer assay.