308266-51-5 Usage
Description
4-Azaspiro[2.4]heptan-5-one, also known as Ropivacaine, is a local anesthetic belonging to the class of 4-Azaspiro compounds. It features a unique spiro ring system and a ketone functional group, which contribute to its efficacy and safety profile in medical applications.
Used in Medical Industry:
4-Azaspiro[2.4]heptan-5-one is used as a local anesthetic for various medical procedures, including epidural and peripheral nerve block anesthesia. It is favored for its long-lasting pain relief without causing significant motor blockage, making it a valuable tool in managing pain during surgery and post-operative care.
4-Azaspiro[2.4]heptan-5-one is used as a safer alternative to other local anesthetics due to its relatively low toxicity and reduced risk of causing cardiac arrhythmias. This preference is particularly relevant for certain medical procedures where minimizing side effects and complications is crucial.
Check Digit Verification of cas no
The CAS Registry Mumber 308266-51-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,8,2,6 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 308266-51:
(8*3)+(7*0)+(6*8)+(5*2)+(4*6)+(3*6)+(2*5)+(1*1)=135
135 % 10 = 5
So 308266-51-5 is a valid CAS Registry Number.
308266-51-5Relevant articles and documents
Ti-mediated chemoselective conversion of cyanoesters and cyanoamides into β-aminoesters and 1-aza-spirolactams bearing a cyclopropane ring
Bertus, Philippe,Szymoniak, Jan
, p. 265 - 267 (2003)
α-Cyanoesters or tertiary α-cyanoamides react with Grignard reagents and Ti(i-PrO)4 to afford respectively β-aminoesters or amides, bearing a cyclopropane ring. Starting from β- or γ-cyanoesters, spirocyclopropanelactams are formed via an in situ cyclopropanation-lactamization sequence.
HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS
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Paragraph 082; 176, (2020/12/11)
The present disclosure describes novel heterocyclic PRMT5 inhibitors and methods for preparing them. The pharmaceutical compositions comprising such PRMT5 inhibitors and methods of using them for treating cancer, infectious diseases, and other PRMT5 associated disorders are also described.
Studies on the titanium-catalyzed cyclopropanation of nitriles
Laroche, Christophe,Harakat, Dominique,Bertus, Philippe,Szymoniak, Jan
, p. 3482 - 3487 (2007/10/03)
The Ti-mediated reaction of Grignard reagents with nitriles was investigated with sub-stoichiometric amounts of titanium isopropoxide. Cyanoesters were converted to spirocyclopropanelactams in good yields using as low as 0.05 eq of Ti(OiPr)sub