308365-71-1

Basic information

• Product Name: (2-Methoxymethoxy-5-methyl-phenyl)-[(2S,3R)-3-propyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-methanone
• Synonyms: (2-Methoxymethoxy-5-methyl-phenyl)-[(2S,3R)-3-propyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-methanone
• CAS NO: 308365-71-1
• Molecular Weight: 417.526
• Mol File: 308365-71-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-Methoxymethoxy-5-methyl-phenyl)-[(2S,3R)-3-propyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Methoxymethoxy-5-methyl-phenyl)-[(2S,3R)-3-propyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-methanone(308365-71-1)
• EPA Substance Registry System: (2-Methoxymethoxy-5-methyl-phenyl)-[(2S,3R)-3-propyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-methanone(308365-71-1)

Safety Data

• Hazardous Substances Data: 308365-71-1(Hazardous Substances Data)

Upstream product

• 25458-49-5 1-(methoxymethoxy)-4-methylbenzene 
• 308365-67-5 (2S,3R)-N-Methoxy-N-methyl-1-(4-tosyl)-3-propyl-2-aziridinecarboxamide 
• 308365-64-2 (2S,3R)-N-Methoxy-N-methyl-3-propyl-2-aziridinecarboxamide 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Synthesis of optically active 3-amino-2,3-dihydrobenzopyran-4-ones by ring transformation of aziridinecarboxamides

Weinreb amides 1 of aziridinecarboxylic acids react with o-lithiated O-methoxymethylphenols 2 to 2-benzoylaziridines 3 which, after O-deprotection, undergo ring transformation by attack of the phenolic hydroxy group at 3-position of the aziridine ring affording optically active 3-aminodihydrobenzopyran-4-ones 5 under acidic conditions. Alternatively, 5-membered benzofuran-3-ones 6 and 7 can be obtained under basic conditions.