3086-91-7 Usage
Description
Furosemide Related Compound B (100 mg) (4-chloro-5-sulfamoylanthranilic acid) is a metabolite of the diuretic drug Furosemide. It is an off-white solid with chemical properties that make it a significant byproduct in the pharmaceutical industry. FUROSEMIDE RELATED COMPOUND B (100 MG) (4-CHLORO-5-SULFAMOYLANTHRANILIC ACID) is derived from the metabolism of Furosemide, which is commonly used to treat edema and hypertension.
Uses
Used in Pharmaceutical Industry:
Furosemide Related Compound B (100 mg) (4-chloro-5-sulfamoylanthranilic acid) is used as a metabolite for understanding the pharmacokinetics and pharmacodynamics of Furosemide. Studying this compound helps researchers and pharmaceutical companies to optimize the drug's efficacy, safety, and dosing regimens.
Used in Research and Development:
In the field of research and development, Furosemide Related Compound B (100 mg) (4-chloro-5-sulfamoylanthranilic acid) serves as a crucial compound for investigating the metabolic pathways of Furosemide and its potential interactions with other drugs or substances. This knowledge can be applied to develop new drugs or improve existing ones, ultimately benefiting patients with edema and hypertension.
Used in Quality Control and Analysis:
Furosemide Related Compound B (100 mg) (4-chloro-5-sulfamoylanthranilic acid) is utilized in the quality control and analysis of Furosemide-containing pharmaceutical products. By monitoring the presence and concentration of this metabolite, manufacturers can ensure the purity, potency, and consistency of their products, maintaining high standards of quality and safety for consumers.
Used in Toxicology Studies:
In toxicology, Furosemide Related Compound B (100 mg) (4-chloro-5-sulfamoylanthranilic acid) is employed to study the potential adverse effects and toxicity of Furosemide. Understanding the metabolic byproducts and their impact on the body can help researchers identify possible side effects, develop strategies to mitigate them, and improve the overall safety profile of the drug.
Used in Environmental Monitoring:
As a metabolite of Furosemide, Furosemide Related Compound B (100 mg) (4-chloro-5-sulfamoylanthranilic acid) can be found in wastewater and environmental samples. It is used in environmental monitoring to assess the presence and concentration of pharmaceutical compounds in the environment, helping to evaluate the potential ecological impact of these substances and inform strategies for reducing their release into the environment.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 1383, 1962 DOI: 10.1021/jo01051a062
Check Digit Verification of cas no
The CAS Registry Mumber 3086-91-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,8 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3086-91:
(6*3)+(5*0)+(4*8)+(3*6)+(2*9)+(1*1)=87
87 % 10 = 7
So 3086-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H7ClN2O4S/c8-4-2-5(9)3(7(11)12)1-6(4)15(10,13)14/h1-2H,9H2,(H,11,12)(H2,10,13,14)
3086-91-7Relevant articles and documents
Oxidation of fursemide by diperiodatocuprate(III) in aqueous alkaline medium-a kinetic study
Angadi, Mahantesh A.,Tuwar, Suresh M.
, p. 165 - 177 (2010)
Fursemide is the chemical compound 4-chloro-2-(furan-2-ylmethylamino)-5- (aminosulfonyl) benzoic acid. It was oxidized by diperiodatocuprate(III) in alkali solutions, and the oxidation products were identified as furfuraldehyde and 2-amino-4-chloro-5-(aminosulfonyl) benzoic acid. The reaction kinetics were studied spectrophotometrically. The reaction was observed to be first order in [oxidant] and fractional order each in [fursemide] and [periodate], whereas added alkali retarded the rate of reaction. The reactive form of the oxidant was inferred to be [Cu(H3IO6)2]-. A mechanism consistent with the experimental results was proposed, in which oxidant interacts with the substrate to give a complex as a pre-equilibrium state. This complex decomposed in a slow step to give a free radical that was further oxidized by reaction with another molecule of DPC to yield 2-amino-4-chloro-5-(aminosulfonyl) benzoic acid and furfuraldehyde in a fast step. This reaction was studied at 25, 30, 35, 40 and 45∈°C, and the activation parameters E a,ΔH #,ΔS # and ΔG # were determined to be 51 kJ · mol -1,48.5 kJ · mol-1,-63.5 J·K -1· mol-1 and 67 kJ · mol-1, respectively. The value of log∈10 A was calculated to be 6.8.
Studies on the photolysis and hydrolysis of furosemide in aqueous solution
Yagi,Kenmotsu,Sekikawa,Takada
, p. 454 - 457 (1991)
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Preparative access to transformation products (TPs) of furosemide: A versatile application of anodic oxidation
Laurencé, Céline,Rivard, Michael,Lachaise, Isabelle,Bensemhoun, Julia,Martens, Thierry
experimental part, p. 9518 - 9521 (2011/12/15)
Furosemide, a pharmaceutical prescribed for the treatment of edema and hypertension, is a known contaminant of water. In this study, chemoselective anodic oxidation was implemented to assist in the identification and the preparation of furosemide transformation products (TPs), i.e., compounds deriving from furosemide and likely to appear in the environment. An aniline and a pyridinium are proposed as plausible TPs and an analytical study of the pyridinium is presented.
