308847-79-2

Basic information

• Product Name: 2(1H)-Pyrimidinone, 4-amino-5-ethenyl- (9CI)
• Synonyms: 2(1H)-Pyrimidinone, 4-amino-5-ethenyl- (9CI)
• CAS NO: 308847-79-2
• Molecular Formula: C6H7N3O
• Molecular Weight: 137.13928
• Product Categories: PYRIMIDINE
• Mol File: 308847-79-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 8.62±0.10(Predicted)
• CAS DataBase Reference: 2(1H)-Pyrimidinone, 4-amino-5-ethenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 4-amino-5-ethenyl- (9CI)(308847-79-2)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 4-amino-5-ethenyl- (9CI)(308847-79-2)

Safety Data

• Hazardous Substances Data: 308847-79-2(Hazardous Substances Data)

Usage

Class of compound

pyrimidinone derivative

Structural characteristics

six-membered heterocyclic ring containing four carbon atoms, one nitrogen atom, and one oxygen atom

Functional groups

a single amino group and an ethenyl group attached to the pyrimidinone ring

Uses

in various organic synthesis and pharmaceutical applications due to its unique structural properties.

Upstream product

• 1122-44-7 5-iodocytosine 
• 75927-49-0 pinacol vinylboronate 

Relevant articles and documents

Vinylating of pyrimidine derivatives

The invention relates to a process for the preparation of vinyl pyrimidines of the formula I wherein R1is hydrogen or a carboxylic ester group, and R2is hydrogen or a group of the formula (a) wherein Rais hydrogen, a protecting group or a group easily hydrolyzable under physiological conditions, by reacting a compound of the formula II wherein R21is hydrogen or a group (a) wherein hydroxy groups are optionally protected, R3is bromo, chloro or iodo, and R1is as above, with a vinyl borane compound in the presence of a Pd complex and a base, and optionally, further reacting a product of formula I wherein R2is hydrogen with a compound of the formula IV wherein Rbis a hydroxy protecting group and Z is a leaving group, in the presence of a Lewis acid catalyst.