30891-53-3 Usage
Description
Adenosine, N,N-dimethyl-2'-O-methyl-, also known as N6,N6,2''-O-Trimethyladenosine (CAS# 30891-53-3), is a modified adenosine derivative with unique properties. It is characterized by the presence of two methyl groups on the nitrogen atoms and a methyl group on the 2'-O position, which may contribute to its specific biological activities and potential applications.
Uses
Used in Biotechnology Industry:
Adenosine, N,N-dimethyl-2'-O-methylis used as a component in methods for enhanced in vivo delivery of synthetic, modified RNAs. Its unique structure may improve the stability, cellular uptake, and overall effectiveness of RNA-based therapies, making it a valuable tool for the development of novel treatments in the biotechnology field.
Check Digit Verification of cas no
The CAS Registry Mumber 30891-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,8,9 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 30891-53:
(7*3)+(6*0)+(5*8)+(4*9)+(3*1)+(2*5)+(1*3)=113
113 % 10 = 3
So 30891-53-3 is a valid CAS Registry Number.
30891-53-3Relevant articles and documents
Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides
Yamauchi, Kiyoshi,Nakagima, Toru,Kinoshita, Masayoshi
, p. 2787 - 2792 (2007/10/02)
Methylations of the naturally occuring ribonucleoside (1), deoxyribonucleoside (2), and 2′-O-methylribonucleoside (3) were carried out using trimethylsulphonium hydroxide (Me3SOH) and trimethylsulphonium iodide (Me3Sl). The base moiety of (2) and (3) are more reactive than the corresponding base moiety of (1). The sites and extent of methylation of (2) are considerably different from those of (1), but are almost identical with those of (3). The reactivities of (1)-(3) are discussed in connection to an intramolecular interaction of the 2′-OH groups with the base moiety of (1). The methylating characteristics of Me 3SOH and Me3Sl are also described. The kinetics indicate an SN2 mechanism for methylation of nucleosides by Me 3S+ ions.
