30913-86-1

Basic information

• Product Name: Methyl4-(4-bromophenyl)-4-oxobutanoate
• Synonyms: Methyl4-(4-bromophenyl)-4-oxobutanoate;Benzenebutanoic acid, 4-broMo-g-oxo-, Methyl ester
• CAS NO: 30913-86-1
• Molecular Formula: C₁₁H₁₁BrO₃
• Molecular Weight: 271.10724
• Mol File: 30913-86-1.mol
• Article Data: 23

Chemical Properties

• Melting Point: 50-52°C
• Boiling Point: 364.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.425±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl4-(4-bromophenyl)-4-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl4-(4-bromophenyl)-4-oxobutanoate(30913-86-1)
• EPA Substance Registry System: Methyl4-(4-bromophenyl)-4-oxobutanoate(30913-86-1)

Safety Data

• Hazardous Substances Data: 30913-86-1(Hazardous Substances Data)

Usage

General Description

Methyl 4-(4-bromophenyl)-4-oxobutanoate, also known as ethyl 2-bromo-2-methylpropanoate, is a chemical compound with the molecular formula C11H11BrO3. It is a yellowish liquid with a fruity odor, commonly used as a reagent in organic synthesis and pharmaceutical research. Methyl4-(4-bromophenyl)-4-oxobutanoate belongs to the class of organic compounds known as alpha-keto esters and is typically used in the preparation of various pharmaceutical products. Additionally, it is considered a potential mutagen, as it may cause genetic mutations in living organisms. Therefore, careful handling and disposal practices are necessary when working with this chemical.

Upstream product

• 186581-53-3 diazomethane 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 32149-27-2 trans-methyl-4-(4-bromophenyl)-4-oxobut-2-enoate 
• 32095-83-3 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid methyl ester 
• 67-56-1 methanol 
• 292638-85-8 acrylic acid methyl ester 
• 20005-42-9 5-(4-bromophenyl)-2-furancarboxyaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 108-86-1 bromobenzene 
• 35513-39-4 β-(4-bromobenzoyl)acrylic acid 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 7477-66-9 4-oxo-4-(4-bromo-phenyl)-trans-crotonic acid-chloride 
• 90766-44-2 (E)-4-oxo-4-(4-bromophenyl)-2-butenamide 
• 851108-42-4 4-(4-bromophenyl)-4-oxobutanamide 

Downstream Products

• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 126135-40-8 methyl 4-hydroxy-4-(4-bromophenyl)butanoate 
• 90991-21-2 4-(4-cyano-phenyl)-4-oxo-butyric acid methyl ester 
• 201531-42-2 5-(4-bromophenyl)-1-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-pyrrolidin-2-one 
• 126135-43-1 (R)-(+)-γ-(p-Bromophenyl)-γ-butyrolactone 
• 509083-36-7 rac-1-(4-bromophenyl)-1,4-butandiol 
• 222714-95-6 4-[4-(5-chloro-thiophen-2-yl)-phenyl]-4-oxo-butyric acid, methyl ester 
• 1041859-45-3 methyl 4-oxo-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolane-2-yl)phenyl]butyrate 
• 1304688-84-3 (1S,2S)-methyl 2-(4-bromophenyl)cyclopropanecarboxylate 
• 1885-28-5 γ-(4-bromophenyl)-γ-butyrolactone 
• 1357165-86-6 methyl 4-[4-(5-nitropyridin-2-yl)phenyl]-4-oxobutyrate 
• 405522-29-4 (3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one 
• 405522-31-8 (R)-5-(4-bromophenyl)-1-((S)-2-hydroxy-1-phenylethyl)pyrrolidin-2-one 
• 405522-33-0 (R)-5-(4-bromophenyl)-1-((S)-2-chloro-1-phenylethyl)pyrrolidin-2-one 

Relevant articles and documents

One-Pot Sequential Photoredox Chemistry and Asymmetric Transfer Hydrogenation with a Single Catalyst

A sequential process is reported, in which different photoredox reactions are placed in sequence with asymmetric transfer hydrogenations of aryl ketones to provide a diverse set of chiral alcohols with enantioselectivities of up to 99 % ee. The method relies on a single chiral-at-metal catalyst which is added at the beginning of the two step sequence and only a final purification of the reaction product is required.

Transition Metal-Free Alkyne-Aldehyde Reductive C?C Coupling trough Cascade Borylation/Olefin Isomerization

A direct approach to γ-keto esters through cascade alkyne-aldehyde reductive C?C coupling of propargyl esters and aromatic aldehydes under transition-metal-free (TM-free) fashion was developed. Compared with multistep processes, this procedure provides a

TBAI/TBHP-Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ-Keto Diesters

A metal-free protocol for oxidative coupling of malonic esters with styrenes to form γ-keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo-catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal-free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ-keto diesters.