30987-77-0

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-(4-morpholinylmethyl)-
• CAS NO: 30987-77-0
• Molecular Formula: C20H19NO8
• Molecular Weight: 401.373
• Mol File: 30987-77-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-(4-morpholinylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-(4-morpholinylmethyl)-(30987-77-0)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-(4-morpholinylmethyl)-(30987-77-0)

Safety Data

• Hazardous Substances Data: 30987-77-0(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 
• 117-39-5 quercetol 

Relevant articles and documents

Modification of quercetin by (dodecylsulfanyl)methyl group

A simple and efficient synthetic protocol for alkylthiomethylation of quercetin was proposed. New sulfur-containing quercetin derivatives were obtained by the reaction of this flavonoid with (N,N-diethylaminomethyl)dodecyl sulfide.

ANTIOXIDANT FLAVONOID DERIVATIVES

The present invention relates to antioxidant flavonoids, compositions containing such antioxidant flavonoids and methods for using such antioxidant flavonoids to treat, e.g., AMD.

Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity

A series of nitrogen-containing flavonoid analogues were designed and synthesized by Mannich reaction, and screened for the inhibitory activities of cyclin-dependent kinases using a FRET-based biochemical assay method. The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities. 5,6,7-Trihydroxy-8-(dimethylaminomethyl)-2-phenyl-4H-chromen-4-one 3a, 5,6,7-trihydroxy-8-(pyrrolid inylmethyl)-2-phenyl-4H-chromen-4-one 3b, and 5,6,7-trihydroxy-8-(piperidinylmethyl)-2-phenyl-4H-chromen-4-one 3c (IC50 1.05-1.28 μM) were about sixfold more potent than baicalein 2 (IC50 6.53 μM). 5,6,7-Trihydroxy-8-(morpholinomethyl)-2-phenyl-4H-chromen-4-one 3d, 5,6,7-trihydroxy-8-(thiomorpholinomethy)-2-phenyl-4H-chrom en-4-one 3e, and 5,6,7-trihydroxy-8-(4-methylpiperazinylmethyl)-2-phenyl-4H-chromen-4-one 3f (IC50 0.27-0.38 μM) were about 20-fold more potent than baicalein, and were at the same level as flavopiridol (IC50 0.33 μM).