31009-93-5

Basic information

• Product Name: Butanamide, 2-chloro-N-(2-chlorophenyl)-3-oxo-
• CAS NO: 31009-93-5
• Molecular Formula: C10H9Cl2NO2
• Molecular Weight: 246.093
• Mol File: 31009-93-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-chloro-N-(2-chlorophenyl)-3-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-chloro-N-(2-chlorophenyl)-3-oxo-(31009-93-5)
• EPA Substance Registry System: Butanamide, 2-chloro-N-(2-chlorophenyl)-3-oxo-(31009-93-5)

Safety Data

• Hazardous Substances Data: 31009-93-5(Hazardous Substances Data)

Upstream product

• 93-70-9 3-oxo-N-2-chlorophenylbutanamide 
• 95-51-2 o-chloroaniline 

Downstream Products

• 59594-43-3 2-Hydroxy-2-methyl-[1,4]oxathiane-3-carboxylic acid (2-chloro-phenyl)-amide 
• 463342-71-4 (1Z)-2-[(2-chlorophenyl)amino]-2-oxo-N-phenylethanehydrazonoyl chloride 
• 463342-75-8 (1Z)-N-(3-chlorophenyl)-2-[(2-chlorophenyl)amino]-2-oxoethanehydrazonoyl chloride 
• 463342-73-6 (1Z)-N-(2-chlorophenyl)-2-[(2-chlorophenyl)amino]-2-oxoethanehydrazonoyl chloride 
• 1198408-77-3 N-(2-chlorophenyl)-2-methyl-6-phenylimidazo[1,2-a]pyridine-3-carboxamide 
• 1198408-34-2 C₁₅H₁₁BrClN₃O 

Relevant articles and documents

Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors

A structure-activity relationship study for a 2-chloroanilide derivative of pyrazolo[1,5-a]pyridine revealed that increased EphB3 kinase inhibitory activity could be accomplished by retaining the 2-chloroanilide and introducing a phenyl or small electron donating substituents to the 5-position of the pyrazolo[1,5-a]pyridine. In addition, replacement of the pyrazolo[1,5-a]pyridine with imidazo[1,2-a]pyridine was well tolerated and resulted in enhanced mouse liver microsome stability. The structure-activity relationship for EphB3 inhibition of both heterocyclic series was similar. Kinase inhibitory activity was also demonstrated for representative analogs in cell culture. An analog (32, LDN-211904) was also profiled for inhibitory activity against a panel of 288 kinases and found to be quite selective for tyrosine kinases. Overall, these studies provide useful molecular probes for examining the in vitro, cellular and potentially in vivo kinase-dependent function of EphB3 receptor.

Synthesis and structural assignment of oxanilo-N-arylhydrazonoyl chlorides

Oxanilo-N-arylhydrazonoyl chlorides have been prepared from appropriate N-aryl-2-chloro-3-oxobutanamides by the Japp-Klingemann reaction. The structures of the title compounds have been established in the solid state by single-crystal X-ray structure determination and IR spectroscopy, and in solution by IR, UV, and 1H and 13C NMR spectroscopy. The results indicate that the hydrazonoyl chloride moiety adopts the (Z)-configured form. In the crystal, intramolecular hydrogen bonds generally exist between the chloride function and the hydrazone hydrogen atom, and also between the amide hydrogen atom and the double-bonded nitrogen atom of the hydrazone moiety. In solution, this intramolecular hydrogen bonding could not be detected. In compounds with an ortho-chloro-substituted NH-aryl moiety, however, the chlorine atom is involved in hydrogen bonding to the NH hydrogen atom both in the crystal and in solution. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.