3103-38-6Relevant articles and documents
Discovery of a new family of dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis
Gui, Chun,Li, Qinglian,Mo, Xuhua,Qin, Xiangjing,Ma, Junying,Ju, Jianhua
supporting information, p. 628 - 631 (2015/03/03)
Bioinformatic analyses indicate that TrdC, SlgL, LipX2, KirHI, and FacHI belong to a group of highly homologous proteins involved in biosynthesis of actinomycete-derived tirandamycin B, streptolydigin, ?±-lipomycin, kirromycin, and factumycin, respectively. However, assignment of their biosynthetic roles has remained elusive. Gene inactivation and complementation, in vitro biochemical assays with synthetic analogues, point mutations, and phylogenetic tree analyses reveal that these proteins represent a new family of Dieckmann cyclases that drive tetramic acid and pyridone scaffold biosynthesis.
Inhibitors of the advanced glycosylation of proteins and methods of use therefor
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, (2008/06/13)
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins resulting from their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
The synthesis of tenuazonic and congeneric tetramie acids.
Harris,Fisher,Folkers
, p. 478 - 482 (2007/10/05)
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