31039-63-1Relevant articles and documents
The first enantioselective total synthesis of lantalucratin C and determination of its absolute configuration
Ogata, Tokutaro,Tanaka, Manami,Ishigaki, Momoe,Shimizu, Maki,Nishiuchi, Arisa,Inamoto, Kiyofumi,Kimachi, Tetsutaro
, p. 6672 - 6680 (2015)
Described here is the first enantioselective total synthesis of lantalucratin C, which was isolated from the rainforest plant Lantana involucrata, and which possesses anti-tumor activity. The OH group on the aromatic ring was systematically introduced by
Unusual, chemoselective etherification of 2-hydroxy-1,4-naphthoquinone derivatives utilizing alkoxymethyl chlorides: Scope, mechanism and application to the synthesis of biologically active natural product (±)-lantalucratin C
Ogata, Tokutaro,Yoshida, Tomoyo,Shimizu, Maki,Tanaka, Manami,Fukuhara, Chie,Ishii, Junko,Nishiuchi, Arisa,Inamoto, Kiyofumi,Kimachi, Tetsutaro
, p. 1423 - 1432 (2017/02/15)
A novel etherification of 2-hydroxy-1,4-naphthoquinone derivatives with alkoxyalkyl chlorides and hydride bases is described. Precise study of the conditions and substrate scope suggested that the reaction occurs specifically in the molecule having a 2-hydroxy-1,4-benzoquinone skeleton. A chemoselective O-methylation reaction was achieved to afford a synthetically important intermediate, which offered easy access to a natural product possessing anti-tumor activity.
Fused quinonic compounds
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Paragraph 0128; 0130, (2014/02/15)
A compound having the formula (I): for use in treating disease; a composition comprising said fused quinonic compound of formula (I) and at least one pharmaceutically acceptable carrier; as well as a method of modulating a Janus Kinase-Signal Transduction
