310442-40-1

Basic information

• Product Name: 4-Chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester
• Synonyms: 4-Chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester;Methyl 4-chloro-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxylate;methyl 4-chloro-5- methylpyrrolo[1,2-f][1,2,4] triazine-6-carboxylate
• CAS NO: 310442-40-1
• Molecular Formula: C₉H₈ClN₃O₂
• Molecular Weight: 225.634
• Product Categories: API intermediates
• Mol File: 310442-40-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• PKA: -3.72±0.30(Predicted)
• CAS DataBase Reference: 4-Chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester(310442-40-1)
• EPA Substance Registry System: 4-Chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester(310442-40-1)

Safety Data

• Hazardous Substances Data: 310442-40-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester is a specific organic compound that belongs to the pyrrolo[2,1-f][1,2,4]triazines class. As the name indicates, this chemical has a methyl ester group, a chlorine atom and a carboxylic acid group on its structure. While there isn't considerable data available regarding its specific use or properties, chemical substances like this are often used in research or as intermediate compounds in the synthesis of more complicated molecules in the pharmaceutical industry. These type of triazine compounds are typically known for their diverse applications and biological activities. However, detailed information about this specific compound, including its physical properties or safety data, appears to be limited or non-existent in the public domain as it may not be widely used or produced.

Upstream product

• 310431-29-9 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310431-26-6 dimethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 40318-15-8 methyl 4-methyl-1H-pyrrole-3-carboxylate 
• 3780-42-5 dimethyl 3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 623-43-8 crotonic acid methyl ester 
• 623-43-8 methyl crotonate 

Downstream Products

• 310442-32-1 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310442-33-2 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 310442-42-3 4-[(3-Carboxyphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid Methyl Ester 
• 310442-44-5 4-[[3-Hydroxy-4-[(phenylsulfonyl)amino]phenyl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310444-81-6 4-phenoxy-5-methyl-6-carbomethoxypyrrolo[2,1-f][1,2,4]triazine 
• 310442-47-8 4-[[3-(Hydroxysulfonyl)phenyl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 1005196-65-5 methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-67-7 methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-64-4 methyl 5-methyl-4-(2-methyl-5-(methylcarbamoyl)phenylamino)pyrrolo[1,2-f][1,2,4]triazine-6-carboxylate 
• 1005196-66-6 C₁₇H₁₇N₅O₃ 
• 427877-58-5 C₁₉H₂₁N₅O₃ 
• 1005196-62-2 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 

Relevant articles and documents

PYRROLOTRIAZINE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors

Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): 1or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups —ZR4R5 taken together comprise an —NH-substituted aryl.