31083-73-5

Basic information

• Product Name: Benzonitrile, 4-(1-oxo-3-phenyl-2-propenyl)-
• CAS NO: 31083-73-5
• Molecular Formula: C16H11NO
• Molecular Weight: 233.269
• Mol File: 31083-73-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(1-oxo-3-phenyl-2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(1-oxo-3-phenyl-2-propenyl)-(31083-73-5)
• EPA Substance Registry System: Benzonitrile, 4-(1-oxo-3-phenyl-2-propenyl)-(31083-73-5)

Safety Data

• Hazardous Substances Data: 31083-73-5(Hazardous Substances Data)

Upstream product

• 1443-80-7 4-cyanophenyl methyl ketone 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 105-07-7 4-cyanobenzaldehyde 
• 93628-96-7 (2E)-3-phenyl-1-(4-cyanophenyl)prop-2-en-1-one 
• 100-42-5 styrene 
• 19710-56-6 hydroxycarbene 
• 126747-14-6 4-cyanophenylboronic acid 

Downstream Products

• 93628-96-7 (2E)-3-phenyl-1-(4-cyanophenyl)prop-2-en-1-one 
• 1180009-49-7 4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzonitrile 
• 143429-16-7 1-(4-cyanophenyl)-3-hydroxy-3-phenyl-1-propanone 
• 259674-54-9 4-(1-hydroxy-3-phenylallyl)benzonitrile 
• 88405-28-1 4-[1-(4-Amino-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-benzonitrile 
• 60695-02-5 4-(1-oxo-3-phenylpropyl)benzonitrile 

Relevant articles and documents

Fluorescent Molecular Logic Gates Driven by Temperature and by Protons in Solution and on Solid

Temperature-driven fluorescent NOT logic is demonstrated by exploiting predissociation in a 1,3,5-trisubstituted Δ2-pyrazoline on its own and when grafted onto silica microparticles. Related Δ2-pyrazolines become proton-driven YES an

Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin

Inflammation and oxidative stress are common in many chronic diseases. Targeting signaling pathways that contribute to these conditions may have therapeutic potential. The transcription factor Nrf2 is a major regulator of phase II detoxification and anti-oxidant genes as well as anti-inflammatory and neuroprotective genes. Nrf2 is widespread in the CNS and is recognized as an important regulator of brain inflammation. The natural product curcumin exhibits numerous biological activities including ability to induce the expression of Nrf2-dependent phase II and anti-oxidant enzymes. Curcumin has been examined in a number of clinical studies with limited success, mainly owing to limited bioavailability and rapid metabolism. Enone analogues of curcumin were examined with an Nrf2 reporter assay to identify Nrf2 activators. Analogues were separated into groups with a 7-carbon dienone spacer, as found in curcumin; a 5-carbon enone spacer with and without a ring; and a 3-carbon enone spacer. Activators of Nrf2 were found in all three groups, many of which were more active than curcumin. Dose-response studies demonstrated that a range of substituents on the aromatic rings of these enones influenced not only the sensitivity to activation, reflected in EC50 values, but also the extent of activation, which suggests that multiple mechanisms are involved in the activation of Nrf2 by these analogues.

Transition-Metal-Free Catalytic Formal Hydroacylation of Terminal Alkynes

Although hydroacylation is a very useful reaction for producing ketones from aldehydes with 100% atom efficiency, classical Rh-catalyzed hydroacylation presents several problems, including the need for transition metal catalysts, unwanted decarbonylation of aldehydes, and difficulty in regioselectivity control. However, formal hydroacylation utilizing the nucleophilicity of terminal alkynes can avoid these problems. In this work, we have achieved transition-metal-free formal hydroacylation of terminal alkynes using an Mg3Al-CO3-layered double hydroxide as a heterogeneous catalyst. This system was applicable to the efficient synthesis of α,β-unsaturated ketones with various substituents, and the catalyst can be reused without a significant loss of catalytic performance.