311-86-4

Basic information

• Product Name: 2-Bromo-3,3,3-trifluoropropan-1-ol
• Synonyms: 2-Bromo-3,3,3-trifluoropropan-1-ol;2-BROMO-3,3,3-TRIFLUORO-1-PROPANOL;2-Bromo-1-hydroxy-3-(trifluoromethyl)propane;2-Bromo-1-hydroxy-3-(trifluoromethyl)propane, 1-Bromo-1-(trifluoromethyl)-2-hydroxyethane;1-Propanol,2-broMo-3,3,3-trifluoro-
• CAS NO: 311-86-4
• Molecular Formula: C₃H₄BrF₃O
• Molecular Weight: 192.9624696
• Mol File: 311-86-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 156.5°Cat760mmHg
• Flash Point: 48.4°C
• Appearance: /
• Density: 1.828g/cm³
• Storage Temp.: 2-8°C
• PKA: 13.30±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3,3,3-trifluoropropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3,3,3-trifluoropropan-1-ol(311-86-4)
• EPA Substance Registry System: 2-Bromo-3,3,3-trifluoropropan-1-ol(311-86-4)

Safety Data

• Hazard Codes: F
• Hazardous Substances Data: 311-86-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-3,3,3-trifluoropropan-1-ol is a chemical compound with the molecular formula C3H4BrF3O. It is a colorless liquid with a slightly sweet odor. 2-Bromo-3,3,3-trifluoropropan-1-ol is used as a pharmaceutical intermediate and reagent, particularly in the synthesis of various chemical products. It is also used in the preparation of fluorinated compounds and as a solvent in various chemical reactions. Additionally, 2-Bromo-3,3,3-trifluoropropan-1-ol has potential applications in the pharmaceutical and agrochemical industries. Due to its chemical properties, it is important to handle and store this substance with care and follow proper safety protocols in its use.

InChI:InChI=1S/C3H4BrF3O/c4-2(1-8)3(5,6)7/h2,8H,1H2

Upstream product

• 677-21-4 1,1,1-trifluoropropylene 
• 383-68-6 3-acetoxy-2-bromo-1,1,1-trifluoropropane 

Downstream Products

• 75-56-9 methyloxirane 
• 359-41-1 1,1,1-trifluoro-2,3-epoxypropane 
• 2240-88-2 3,3,3-Trifluoropropanol 
• 167951-80-6 4-(trifluoromethyl)-1,3-dioxolan-2-one 
• 431-39-0 (rac)-3,3,3-trifluoro-1,2-propanediol 
• 1514-82-5 2-bromo-3,3,3-trifluoropropene 

Relevant articles and documents

Preparation method of 3,3,3-trifluoropropylene carbonate

The invention discloses a preparation method of 3,3,3-trifluoropropylene carbonate. The preparation method comprises the steps: with trifluoropropylene as a raw material, carrying out several simple reaction steps to obtain trifluoroepoxy propane, introducing carbon dioxide into a high-pressure reaction kettle by taking a metal conjugated microporous polymer complex as a catalyst, and preparing 3,3,3-trifluoropropylene carbonate at the temperature of 25-100 DEG C and the pressure of 0.1Mpa-3Mpa. Compared with the prior art, the method has the advantages that trifluoropropylene is taken as theraw material, so that the raw material cost is substantially lowered; and meanwhile, the yield is relatively high, and the catalyst can be repeatedly used, so that the method is suitable for industrial production.

A method for preparing three fluorine epoxy propane

The invention relates to a preparation method of trifluoro epoxypropane, which comprises the following steps: (1) in the presence of sulfuric acid, performing reflux reaction on 3,3,3-trifluoro-2-bromopropyl acetate and alcohol to prepare 3,3,3-trifluoro-2-bromopropanol; and (2) dropwisely adding the 3,3,3-trifluoro-2-bromopropanol into a mixture of alkali and water at 70-120 DEG C, and reacting to prepare trifluoro epoxypropane. According to the invention, the 3,3,3-trifluoro-2-bromopropyl acetate used as a raw material is subjected to ester exchange to obtain the 3,3,3-trifluoro-2-bromopropanol, the treatment method is simple, green and environment-friendly; a catalyst concentrated sulfuric acid is reusable; and the preparation efficiency of the 3,3,3-trifluoro-2-bromopropanol is high. Meanwhile, the trifluoro epoxypropane reaction yield is high.

Preparative-scale synthesis of 3,3,3-trifluoropropene oxide

Bromination of 3,3,3-trifluoropropene in 20% oleum, followed by treatment with acetic acid furnishes 2-bromo-3,3,3-trifluoropropyl acetate in quantitative yield, which upon acid hydrolysis and cyclization with alkali affords 3,3,3-trifluoropropene oxide (TFPO) in 63% overall yield.