311770-45-3Relevant articles and documents
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor α subtype-selective activators
Nomura, Masahiro,Tanase, Takahiro,Ide, Tomohiro,Tsunoda, Masaki,Suzuki, Masahiro,Uchiki, Hideharu,Murakami, Koji,Miyachi, Hiroyuki
, p. 3581 - 3599 (2007/10/03)
Substituted phenylpropanoic acid derivatives were prepared as part of a search for subtype-selective human peroxisome proliferator activated receptor α (PPARα) activators. Structure-activity relationship studies indicated that the nature and the stereoche
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: Novel human PPARα-selective activators
Miyachi, Hiroyuki,Nomura, Masahiro,Tanase, Takahiro,Takahashi, Yukie,Ide, Tomohiro,Tsunoda, Masaki,Murakami, Koji,Awano, Katsuya
, p. 77 - 80 (2007/10/03)
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
