312-44-7

Basic information

• Product Name: 2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID
• Synonyms: 2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID;2-(4-FLUOROPHENYL)ALANINE
• CAS NO: 312-44-7
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.18
• Product Categories: pharmacetical
• Mol File: 312-44-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 296.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.288±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.95±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID(312-44-7)
• EPA Substance Registry System: 2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID(312-44-7)

Safety Data

• Hazardous Substances Data: 312-44-7(Hazardous Substances Data)

Usage

General Description

2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID is a compound with the chemical formula C9H10FNO2. It is a derivative of propanoic acid and contains an amino group and a fluorine-substituted phenyl group. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It may also have potential applications in medicinal chemistry and drug discovery due to its structural features. Additionally, it may have biological activity and could be used as a research tool in biochemical and pharmacological studies.

Upstream product

• 428-22-8 5-(4-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Relevant articles and documents

New enzymatic methods for the synthesis of primary α-aminonitriles and unnatural α-amino acids by oxidative cyanation of primary amines with d-amino acid oxidase from porcine kidney

Oxidation of amino groups in amines or amino acids activates the sp3 Cα-H bond to form imines, making the alpha carbon atom a preferable target for nucleophilic reagents such as cyanide. Therefore, we focused on the oxidase reaction for the production of primary α-aminonitriles via imines. d-Amino acid oxidase from porcine kidney (pkDAO) and l-amino acid oxidase from Crotalus atrox catalyzed the synthesis of 2-amino-2-cyano-3-phenylpropanoic acid from phenylalanine and potassium cyanide (KCN). Mutant pkDAO (Y228L/R283G) catalyzed the synthesis of racemic-2-methyl-2-phenylglycinonitrile from (R)-α-methylbenzylamine and KCN. Based on these results, we developed a new cascade reaction for the synthesis of unnatural α-amino acids from primary amines using mutant pkDAO and nitrilase AY487533. This is the first report of the enzymatic synthesis of primary α-aminonitriles and unnatural α-amino acids. These methods will contribute widely to the synthesis of primary α-aminonitriles and unnatural α-amino acids in aqueous systems.