312-94-7 Usage
Description
2-(Trifluoromethyl)benzoyl chloride is an organic compound with the chemical formula C8H4ClF3O2. It is a colorless to light yellow liquid at room temperature and possesses a distinctive aromatic odor. 2-(Trifluoromethyl)benzoyl chloride is characterized by the presence of a trifluoromethyl group (-CF3) attached to the benzene ring at the 2nd position and a benzoyl chloride group (-C(O)Cl) attached to the same benzene ring. The trifluoromethyl group imparts unique chemical and physical properties to the molecule, making it a versatile building block in various chemical reactions and synthesis processes.
Uses
Used in Chemical Synthesis:
2-(Trifluoromethyl)benzoyl chloride is used as an intermediate in the synthesis of various organic compounds, particularly those involving the trifluoromethyl group. The application reason for its use in chemical synthesis is due to its reactivity and the unique properties conferred by the trifluoromethyl group, which can enhance the stability, lipophilicity, and metabolic stability of the final products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Trifluoromethyl)benzoyl chloride is used as a key building block for the synthesis of various drug candidates. The trifluoromethyl group is known to improve the pharmacokinetic properties of drugs, such as absorption, distribution, metabolism, and excretion (ADME) profiles. As a result, incorporating this group into drug molecules can lead to improved efficacy and reduced side effects.
Used in Agrochemical Industry:
2-(Trifluoromethyl)benzoyl chloride is also utilized in the agrochemical industry for the development of new pesticides and herbicides. The trifluoromethyl group can enhance the biological activity and selectivity of these compounds, leading to more effective and environmentally friendly products.
Used in Material Science:
In the field of material science, 2-(Trifluoromethyl)benzoyl chloride can be employed in the synthesis of novel polymers and materials with enhanced properties. The introduction of the trifluoromethyl group can improve the thermal stability, mechanical strength, and chemical resistance of the resulting materials, making them suitable for various applications, such as coatings, adhesives, and plastics.
Check Digit Verification of cas no
The CAS Registry Mumber 312-94-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 2 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 312-94:
(5*3)+(4*1)+(3*2)+(2*9)+(1*4)=47
47 % 10 = 7
So 312-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H3ClFN/c6-5-2-1-4(7)3-8-5/h1-3H
312-94-7Relevant articles and documents
Synthetic method of o-trifluoromethyl benzoyl chloride
-
, (2022/03/27)
The invention discloses a synthesis method of o-trifluoromethyl benzoyl chloride, o-xylene is used as a starting raw material, the o-trifluoromethyl benzoyl chloride is synthesized through chlorination, fluorination, hydrolysis, acylating chlorination and rectification reaction in sequence, and the invention further provides ceramic balls, a modified TPU material and a fluorination auxiliary agent used in the synthesis method of the o-trifluoromethyl benzoyl chloride. According to the method, the low-toxicity color liquid o-xylene is adopted as the initial raw material, the reaction safety is high, and the yield of the target product o-trifluoromethyl benzoyl chloride is comprehensively improved by improving the utilization rate of chlorine and hydrogen fluoride and reducing by-products.
Synthesis method of fluopyram intermediate
-
Paragraph 0008; 0011-0012; 0015-0016; 0019-0020; 0023-0024, (2021/06/22)
The invention discloses a synthesis method of a fluopyram intermediate, and belongs to the field of organic synthesis of pesticides. The process comprises the following steps: by taking methanol amine as a starting raw material, carrying out esterification reaction on methanol amine and acetic anhydride in the presence of acetic acid to obtain methyl aminoacetate, and carrying out amidation reaction on methyl aminoacetate and o-trifluoromethyl benzoyl chloride to obtain N-acetoxymethyl-2-trifluoromethyl benzamide; and finally, carrying out a splicing reaction with diethyl 3-chloro-5-trifluoromethyl-2-pyridylmalonate, so as to obtain the 3-chloro-5-trifluoromethyl-2-pyridylethyl (diethyl ester)-2-trifluoromethyl benzamide. The method adopts a convergent synthesis route, has the characteristics of low raw material cost, high atom economy, high yield, simple process operation and the like, and is suitable for large-scale production.
Copper-mediated C–H thiolation of (hetero)arenes using weakly coordinating directing group
Wu, Peng,Cheng, Tai-Jin,Lin, Hai-Xia,Xu, Hui,Dai, Hui-Xiong
supporting information, (2020/06/17)
We have developed a copper-mediated C–H thiolation of (hetero)arenes by using monodentate amide as weakly coordinating directing group. This protocol features excellent functional group tolerance and shows satisfactory compatibility with various heterocycles, such as indole, pyrrole, imidazole, pyridine, thiophene and quinoline. The robust nature of this protocol renders that it has potential value in the synthetic application.
