312276-02-1

Basic information

• Product Name: 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester
• Synonyms: 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester
• CAS NO: 312276-02-1
• Molecular Weight: 344.367
• Mol File: 312276-02-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester(312276-02-1)
• EPA Substance Registry System: 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester(312276-02-1)

Safety Data

• Hazardous Substances Data: 312276-02-1(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 2972-80-7 3,4-dimethoxybenzylidenemalononitrile 

Downstream Products

• 702698-96-2 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-3-pyridinecarboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of functionalized chromene and spirochromenes using L-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature

An efficient and recyclable homogeneous catalyst is developed using commercially cheap L-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, L-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity.