312298-31-0Relevant articles and documents
Reaction of N-acylated isofebrifugine with acid
Takeuchi, Yasuo,Azuma, Kumiko,Abe, Hitoshi,Harayama, Takashi
, p. 2247 - 2252 (2000)
The reaction of N-acylated isofebrifugine with hydrochloric acid is discussed. Although the corresponding deprotected compound was not isolated, three new heterocyclic compounds were obtained. Based on these findings, new furan and pyrrole derivatives wer
Concise synthesis of dl-febrifugine
Takeuchi, Yasuo,Oshige, Miyo,Azuma, Kumiko,Abe, Hitoshi,Harayama, Takashi
, p. 868 - 869 (2007/10/03)
Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).