312325-73-8Relevant articles and documents
COMPOUNDS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISORDERS
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Page/Page column 19; 20, (2022/03/07)
The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent in?ammatory and autoimmune diseases, especially neuroinflammation diseases using the compound.
Aminopyridyloxypyrazole derivative and preparation method and application thereof
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Paragraph 0170; 0173; 0179-0181, (2021/05/19)
The invention relates to an aminopyridyloxypyrazole derivative and a preparation method and application thereof. The structure of the aminopyridyloxypyrazole derivative is shown as a formula (I). The invention provides a brand-new aminopyridyloxypyrazole derivative which has obvious effects of inhibiting TGF [beta] R1 (ALK5) kinase activity and treating cancer or fibrosis related diseases, and the preparation method of the derivative is simple and easy to operate.
Facile cyanomethylation of bromopyridines by nucleophilic substitution with lithioacetonitrile
Skerlj,Bogucki,Bridger
, p. 1488 - 1490 (2007/10/03)
Substituted bromopyridines undergo facile nucleophilic substitution with lithioacetonitrile under mild conditions to afford the corresponding cyanomethylated products.