312488-31-6

Basic information

• Product Name: [(3α,5α,16β,17β)-3,17-dihydroxyandrostan-17-yl]methyl p-toluenesulfonate
• Synonyms: [(3α,5α,16β,17β)-3,17-dihydroxyandrostan-17-yl]methyl p-toluenesulfonate
• CAS NO: 312488-31-6
• Molecular Weight: 476.678
• Mol File: 312488-31-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(3α,5α,16β,17β)-3,17-dihydroxyandrostan-17-yl]methyl p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: [(3α,5α,16β,17β)-3,17-dihydroxyandrostan-17-yl]methyl p-toluenesulfonate(312488-31-6)
• EPA Substance Registry System: [(3α,5α,16β,17β)-3,17-dihydroxyandrostan-17-yl]methyl p-toluenesulfonate(312488-31-6)

Safety Data

• Hazardous Substances Data: 312488-31-6(Hazardous Substances Data)

Upstream product

• 98391-23-2 (3α,5α)-3-hydroxy-16-hydroxymethyleneandrostan-17-one 
• 53-41-8 cis-androsterone 
• 98-59-9 p-toluenesulfonyl chloride 
• 312488-30-5 (3α,5α,16β,17β)-16-hydroxymethylandrostane-3,17-diol 

Relevant articles and documents

Conformationally constrained anesthetic steroids that modulate GABA(A) receptors

Various cyclic ether and other 3α-hydroxyandrostane derivatives bearing a conformationally constrained hydrogen-bonding moiety were prepared. Their anesthetic potency and their binding affinity for GABA(A) receptors, measured by intravenous administration to mice and inhibition of [35S]TBPS binding to rat whole brain membranes, were compared with that of known anesthetic 3α-hydroxypregnan-20-ones. Synthetic steroids with similar in vitro and in vivo activities to the endogenous 3α-hydroxypregnan-20-ones all had an ether oxygen on the β-face of the steroid D-ring. These results suggest that for optimal GABA(A) receptor modulation, the hydrogen bond-accepting substituent should be near perpendicular to the plane of the D-ring on the β-face of the steroid.