312746-74-0

Basic information

• Product Name: 1H-Indazole-7-carboxamide(9CI)
• Synonyms: 1H-Indazole-7-carboxamide(9CI);1H-Indazole-7-carboxamide
• CAS NO: 312746-74-0
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.16
• Product Categories: AMIDE
• Mol File: 312746-74-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 483.5 °C at 760 mmHg
• Flash Point: 246.2 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 1.67E-09mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.43±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole-7-carboxamide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-7-carboxamide(9CI)(312746-74-0)
• EPA Substance Registry System: 1H-Indazole-7-carboxamide(9CI)(312746-74-0)

Safety Data

• Hazardous Substances Data: 312746-74-0(Hazardous Substances Data)

Usage

General Description

1H-Indazole-7-carboxamide(9CI) is a chemical compound with the molecular formula C9H8N4O. It is a derivative of the heterocyclic compound indazole, which is known for its diverse pharmacological properties. 1H-Indazole-7-carboxamide(9CI) has been studied for its potential as a drug candidate in various medical applications, including as an anti-inflammatory and analgesic agent. The compound's structure and properties make it a promising candidate for further research and development in the pharmaceutical industry. Its potential therapeutic effects and pharmacological profile make it a compound of interest for drug development and discovery.

InChI:InChI=1/C8H7N3O/c9-8(12)6-3-1-2-5-4-10-11-7(5)6/h1-4H,(H2,9,12)(H,10,11)

Upstream product

• 677304-69-7 1H-indazole-7-carboxylic acid 

Downstream Products

• 952479-68-4 2-(4-nitrophenyl)-2H-indazole-7-carboxamide 
• 952475-01-3 2-(4-formylphenyl)-2H-indazole-7-carboxamide 

Relevant articles and documents

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preference for constitutive NOS over inducible NOS. By contrast, 1H-indazole-7-carboxamide (8) was slightly less potent but demonstrated a surprising selectivity for the neuronal NOS. Further substitution of 6 by a Br-atom at carbon-3 of the heterocycle enhanced 10-fold the inhibitory effects. Inhibition of NO formation by 6 appeared to be competitive versus both substrate and the cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H4B). In close analogies with 1, compound 6 strongly inhibited the NADPH oxidase activity of nNOS and induced a spin state transition of the heme-FeIII. Our results are explained with the help of the X-ray structures that identified key-features for binding of 1 at the active site of NOS.