313-56-4

Basic information

• Product Name: 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE
• Synonyms: 2,2,2-Trifluoro-1-(2,4,6-trimethyl-phenyl)-ethanone;2,2,2-Trifluoro-1-mesitylethanone;2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE;Ethanone, 2,2,2-trifluoro-1-(2,4,6-trimethylphenyl)- (9CI);2,2,2-Trifluoro-2',4',6'-trimethylacetophenone 97%;2,2,2-Trifluoro-2',4',6'-trimethylacetophenone97%;2,2,2-Trifluoro-1-(2,4,6-trimethylphenyl)ethan-1-one, 2-(Trifluoroacetyl)mesitylene
• CAS NO: 313-56-4
• Molecular Formula: C₁₁H₁₁F₃O
• Molecular Weight: 216.2
• Product Categories: ACETYLHALIDE;C11 to C12;Carbonyl Compounds;Ketones;Building Blocks;C11 to C12;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 313-56-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 70-80 °C20 mm Hg(lit.)
• Flash Point: 170 °F
• Appearance: /
• Density: 1.136 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.456(lit.)
• CAS DataBase Reference: 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE(313-56-4)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE(313-56-4)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 313-56-4(Hazardous Substances Data)

Usage

Uses

2,2,2-Trifluoro-2′,4′,6′-trimethylacetophenone may be used for organic synthesis.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 407-25-0 trifluoroacetic anhydride 
• 102626-53-9 1-(2,4,6-trimethylphenyl)-2,2,2-trifluoroethanol 

Downstream Products

• 102967-65-7 2-(2,4,6-trimethylphenyl)-2-trimethysilyloxy-3,3,3-trifluoropropionitrile 
• 102626-53-9 (R)-2,2,2-trifluoro-1-(2,4,6-trimethylphenyl)ethanol 
• 248245-58-1 (S)-2,2,2-trifluoro-1-(2,4,6-trimethylphenyl)ethanol 
• 139050-56-9 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-2,2,2-trifluoro-1-(2,4,6-trimethyl-phenyl)-ethyl ester 
• 131832-03-6 (S)-Methoxy-phenyl-acetic acid (R)-2,2,2-trifluoro-1-(2,4,6-trimethyl-phenyl)-ethyl ester 
• 131832-03-6 (S)-Methoxy-phenyl-acetic acid (S)-2,2,2-trifluoro-1-(2,4,6-trimethyl-phenyl)-ethyl ester 
• 1605313-69-6 (E)-ethyl 2,4,4,4-tetrafluoro-3-mesitylbut-2-enoate 
• 1605313-70-9 (Z)-ethyl 2,4,4,4-tetrafluoro-3-mesitylbut-2-enoate 

Relevant articles and documents

Organocatalytic Aerobic Oxidation of α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room Temperature

The organocatalytic aerobic oxidation of electron-deficient α-fluoroalkyl alcohols at room temperature is described. The resulting fluoroalkyl ketones are versatile synthetic intermediates for a variety of fluorine-containing molecules. This otherwise difficult transformation has now been accomplished by the reaction of α-fluoroalkyl alcohols with N-oxyl radicals, catalytically generated from 9-azabicyclo[3.3.1]nonan-3-one N-oxyl/nitrogen oxide (keto-ABNO/NOx) and oxygen in acetic acid (AcOH), affording the corresponding fluoroalkyl ketones in high yield. This operationally simple reaction can be performed under mild conditions, and was applied to a wide range of alcohols (20 examples), thus demonstrating a high functional group tolerance. Moreover, a modified one-pot protocol based on this method was able to convert an aldehyde to a trifluoromethyl ketone on a gram scale.

Enantioselective Reduction of Aryl Trifluoromethyl Ketones with BINAL-H. A Preparation of 2,2,2-Trifluoro-1-(9-anthryl)ethanol

-