3132-64-7 Usage
Description
1-Bromo-2,3-epoxypropane, also known as Bromohydrin pyrophosphate, is a colorless volatile liquid with a flash point of 22°F. It is slightly soluble in water and denser than water. 1-Bromo-2,3-epoxypropane is toxic by inhalation and ingestion and is a strong skin irritant. It is an epoxide that is oxirane substituted by a bromomethyl group at position 2.
Uses
1. Used in Pharmaceutical Industry:
1-Bromo-2,3-epoxypropane is used as an enhancer for antibody-dependent cell-mediated cytotoxicity (ADCC) induced by therapeutic antibodies. This application is particularly relevant in the development of targeted cancer therapies, where the compound can improve the effectiveness of antibody-based treatments.
2. Used in Chemical Synthesis:
1-Bromo-2,3-epoxypropane is used as a building block or intermediate in the synthesis of various organic compounds, including pharmaceuticals and other specialty chemicals. Its unique structure allows for a range of reactions, making it a versatile component in chemical manufacturing.
3. Used in Rubber Industry:
1-Bromo-2,3-epoxypropane is used in the rubber industry, where it plays a role in the production of certain types of rubber. Its properties contribute to the desired characteristics of the final rubber product, such as its strength, flexibility, and durability.
Air & Water Reactions
Highly flammable. Slightly soluble in water. Sensitive to prolonged exposure to light and moisture.
Reactivity Profile
1-Bromo-2,3-epoxypropane reacts with acids, bases, oxidizing agents, Na, Zn, Al, Mg and their alloys. .
Health Hazard
TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Human mutation data
reported. A dangerous fire hazard when
exposed to heat or flame. When heated to
decomposition it emits toxic fumes of Br-.
See also BROMIDES.
Check Digit Verification of cas no
The CAS Registry Mumber 3132-64-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,3 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3132-64:
(6*3)+(5*1)+(4*3)+(3*2)+(2*6)+(1*4)=57
57 % 10 = 7
So 3132-64-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H5BrO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m1/s1
3132-64-7Relevant articles and documents
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Clarke,Williams
, p. 1126,1127 (1966)
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Synthesis, Characterization, and Application of Oxo-Molybdenum(V)-Corrolato Complexes in Epoxidation Reactions
Nayak, Manisha,Nayak, Panisha,Sahu, Kasturi,Kar, Sanjib
supporting information, p. 11654 - 11662 (2020/10/23)
Sharpless et al. have described, while performing the molybdenum-catalyzed epoxidation reaction of olefins using alkyl hydroperoxides, that the molybdenum-oxo moiety is an active catalytic species. Thus, continuous efforts have been made to synthesize molybdenum-oxo complexes of different ligand environments. While plenty of such works on molybdenum porphyrins are reported in the literature, related molybdenum corroles are very less reported. The synthesis and characterization of two new oxo-molybdenum(V)-corrolato complexes are described herein. Both the complexes have been fully characterized by several spectroscopic techniques in conjunction with single-crystal X-ray diffraction analysis. The efficacy of the oxo-molybdenum(V)-corrolato complexes for the catalytic epoxidation reaction of olefins with the help of hydroperoxides has also been explored. The catalytic application of oxo-molybdenum(V)-corrolato complexes in the epoxidation reaction has not been reported earlier. A mechanism has been proposed to explain the experimental findings.
Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents
Xu, Yao,Chen, Shujun,Cao, Ying,Zhou, Pingzheng,Chen, Zhipeng,Cheng, Kui
, p. 253 - 266 (2018/05/29)
Toll-like receptor 4 (TLR4) initiates innate immune response to release inflammatory cytokines and has been pathologically linked to variety of inflammatory diseases. Recently, we found that Carvedilol, as the classic anti-heart failure and anti-inflammatory clinic drug, could inhibit the TLR4 signaling in the TLR4 overexpressed cells. Herein, we have designed and synthesized a small library of novel Carvedilol derivatives and investigated their potential inhibitory activity. The results indicate that the most potent compound 8a (SMU-XY3) could effectively inhibited TLR4 protein and the LPS triggered alkaline phosphatase signaling in HEK-Blue hTLR4 cells. It down regulated the nitric oxide (NO) in both RAW264.7 cells and BV-2 microglial cells, in addition to blocking the TNF-α signaling in ex-vivo human peripheral blood mononuclear cells (PBMC). More interestingly, 8a shows higher affinity to hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) over HCN2, which probably indicates the new application of TLR4 inhibitor 8a in heart failure, coronary heart disease, and other inflammatory diseases.