313225-01-3

Basic information

• Product Name: (1H-benzo[d][1,2,3]triazol-1-yl)(4-bromophenyl)methanone
• Synonyms: (1H-benzo[d][1,2,3]triazol-1-yl)(4-bromophenyl)methanone
• CAS NO: 313225-01-3
• Molecular Weight: 302.13
• Mol File: 313225-01-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (1H-benzo[d][1,2,3]triazol-1-yl)(4-bromophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-benzo[d][1,2,3]triazol-1-yl)(4-bromophenyl)methanone(313225-01-3)
• EPA Substance Registry System: (1H-benzo[d][1,2,3]triazol-1-yl)(4-bromophenyl)methanone(313225-01-3)

Safety Data

• Hazardous Substances Data: 313225-01-3(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 586-76-5 4-Bromobenzoic acid 
• 586-75-4 4-chlorobenzoyl chloride 

Downstream Products

• 6341-55-5 N,N'-bis(p-bromophenyl)urea 
• 13114-92-6 1-(4-bromophenyl)-3-phenyl-urea 
• 33415-02-0 1-(p-Brombenzoyl)-2-ethoxycarbonylhydrazin 
• 40427-42-7 isopropyl (4-bromophenyl)carbamate 
• 25203-35-4 1-propyl (4-bromophenyl)carbamate 
• 7451-53-8 ethyl N-(4-bromophenyl)carbamate 
• 25203-36-5 methyl N-(4-bromophenyl)carbamate 
• 25203-33-2 prop-2-yn-1-yl-N-(4-bromophenyl)carbamate 
• 14367-97-6 1-(4-bromophenyl)-2-nitro-1-ethanone 
• 26510-95-2 ethyl 4-Bromobenzoylacetate 

Relevant articles and documents

Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies

Benzotriazoles (4–6) were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7–40). The synthetic compounds (7–40) were characterized via different spectroscopic techniques including EI-MS, HREI-MS, 1H-, and 13C NMR. These molecules were examined for their anti-hyperglycemic potential hence were evaluated for α-glucosidase and α-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00–5.6 and 2.04–5.72 μM against α-glucosidase and α-amylase enzymes, respectively. The synthetic compounds were divided into two categories “A” and “B”, in order to understand the structure-activity relationship. Compounds 25 (IC50 = 2.41 ± 1.31 μM), (IC50 = 2.5 ± 1.21 μM), 36 (IC50 = 2.12 ± 1.35 μM), (IC50 = 2.21 ± 1.08 μM), and 37 (IC50 = 2.00 ± 1.22 μM), (IC50 = 2.04 ± 1.4 μM) with chloro substitution/s at aryl ring were found to be most active against α-glucosidase and α-amylase enzymes. Molecular docking studies on all compounds were performed which revealed that chloro substitutions are playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic molecules have shown competitive mode of inhibition against α-amylase and non-competitive mode of inhibition against α-glucosidase enzyme.

Visible-Light-Induced C(sp2)-P Bond Formation by Denitrogenative Coupling of Benzotriazoles with Phosphites

A visible-light-induced denitrogenative phosphorylation of benzotriazoles is presented, in which diverse substituted aryl phosphonates could be obtained in good to excellent yields. This efficient protocol exhibits good tolerance with various functional g

A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones

A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in acc