31338-08-6

Basic information

• Product Name: tryptophan butyl ester
• Synonyms: tryptophan butyl ester;(S)-2-Amino-3-(1H-indol-3-yl)propionic acid butyl ester;L-Tryptophan butyl ester
• CAS NO: 31338-08-6
• Molecular Formula: C₁₅H₂₀N₂O₂
• Molecular Weight: 260.33
• Mol File: 31338-08-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 423.714°C at 760 mmHg
• Flash Point: 210.055°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: tryptophan butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: tryptophan butyl ester(31338-08-6)
• EPA Substance Registry System: tryptophan butyl ester(31338-08-6)

Safety Data

• Hazardous Substances Data: 31338-08-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H20N2O2/c1-2-3-8-19-15(18)13(16)9-11-10-17-14-7-5-4-6-12(11)14/h4-7,10,13,17H,2-3,8-9,16H2,1H3/t13-/m0/s1

Upstream product

• 73-22-3 L-Tryptophan 
• 71-36-3 butan-1-ol 
• 6330-20-7 L-tryptophan n-butyl ester hydrochloride 

Downstream Products

• 71-36-3 butan-1-ol 

Relevant articles and documents

Synthesis and antifungal activity against fusarium oxysporum of some brassinin analogs derived from L-Tryptophan: A DFT/B3LYP study on the reaction mechanism

An efficient methodology to obtain novel antifungal analogs of brassinin 1 is described. Starting from L-Tryptophan 2, N,N0-dialkylthiourea 4, 4-[(1H-indol-3-yl)methylene]-2-sulfanylidene- 1,3-Thiazolidin-5-one 5 and alkyl (2S)-3-(1H-indol-3-yl)-2-{[(alkylsulfanyl)carbonothioyl]amino} propanoate 6 type compounds were obtained as main products in different ratios depending on the reaction conditions via a tandem dithiocarbamate formation and Michael addition reaction. In order to understand the dependence of the reaction conditions on the mechanism pathway, a DFT/B3LYP study was performed. The results suggested the existence of competitive mechanistic routes which involve the presence of an ionic dithiocarbamate intermediate 9. Antifungal activities of all products were then evaluated against Fusarium oxysporum through mycelial growth inhibition using a microscale amended-medium assay. IC50 values were thus determined for each compound. These results showed that 6-related compounds can be considered as promissory antifungal agents.

COMPOUND SUITABLE FOR THE TREATMENT OF SYNUCLEOPATHIES

The present invention relates to a compound of formula (I): Wherein R1 is a substituted or unsubstituted aromatic hetero- or homocyclic or a substituted or unsubstituted alicyclic hetero- or homocyclic group; R2 is an alkyl group with 1 to 18 carbon atoms or a substituted or unsubstituted cycloalkyl or aryl group; R3 is a substituted or unsubstituted aromatic hetero- or homocyclic or a substituted or unsubstituted alicyclic hetero- or homocyclic group; L is a single bond, an alkyl group having 1 to 6 carbon atoms, NHCO, O, S, NHCONH or NHCOO; X, Y and Z are independently 0, N, NH, S or CH; W is a single bond or an alkyl group having from 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of said compound or salt. I