313527-44-5

Basic information

• Product Name: 2-benzyl-1,3-benzoxazol-5-amine
• Synonyms: 2-benzyl-1,3-benzoxazol-5-amine;2-(PHENYLMETHYL)-5-BENZOXAZOLAMINE;5-BENZOXAZOLAMINE, 2-(PHENYLMETHYL)-;UKRORGSYN-BB BBV-074737
• CAS NO: 313527-44-5
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.26
• Mol File: 313527-44-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-benzyl-1,3-benzoxazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-1,3-benzoxazol-5-amine(313527-44-5)
• EPA Substance Registry System: 2-benzyl-1,3-benzoxazol-5-amine(313527-44-5)

Safety Data

• Hazardous Substances Data: 313527-44-5(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 137-09-7 2,4-diaminophenol dihydrochloride 
• 95-86-3 2,4-diaminophenol 

Downstream Products

• 925584-55-0 C₂₃H₁₆N₂O₃ 
• 1610037-91-6 2-benzyl-5-(4-nitrophenylsulfonamido)benzoxazole 

Relevant articles and documents

Synthesis, molecular docking and antimicrobial evaluation of novel benzoxazole derivatives

In this research, previously and newly synthesized 5-amino-2-(4-substitutedphenyl/benzyl)benzoxazoles (3a-3l) and 2-substituted-5-(4-nitro/aminophenylsulfonamido)benzoxazoles (5a-5l, 6a-6l) were evaluated for their antimicrobial activities against Pseudom

Synthesis and biological evaluation of 2-substituted-5-(4- nitrophenylsulfonamido)benzoxazoles as human GST P1-1 inhibitors, and description of the binding site features

Glutathione-S-transferases (GSTs) are enzymes involved in cellular detoxification by catalyzing the nucleophilic attack of glutathione (GSH) on the electrophilic center of numerous of toxic compounds and xenobiotics, including chemotherapeutic drugs. Huma

Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles

Some new 2-(benzyl/p-chlorobenzyl)-5-[(substituted-thienyl/phenyl/phenylthiomethyl/benzyl)carbonylamino]benzoxazole derivatives have been synthesized by reacting 5-amino-2-(benzyl/p-chlorobenzyl)benzoxazoles with appropriate carboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR, 1H NMR and MASS spectral data. In vitro antimicrobial activities of the compounds were investigated using twofold serial dilution technique against different two Gram-positive, two Gram-negative bacteria and three Candida spp. in comparison with standard drugs. Microbiological results indicated that the newly synthesized 2-(benzyl/p-chlorobenzyl)-5-[(substituted-thienyl/phenyl/phenylthiomethyl/benzyl)carbonylamino]benzoxazole derivatives (3-12) possessed a broad spectrum of activity having MIC values of 6.25-100 μg/ml against the tested microorganisms. Especially, with an MIC value of 6.25 μg/ml, 2-(p-chlorophenyl)-5-[(2,5-dimethylphenyl)carbonylamino]benzoxazole 4 displayed the same activity against Candida albicans as the standard drug clotrimazole.