31354-57-1

Basic information

• Product Name: Formamide, N-2-pyrimidinyl- (6CI,9CI)
• Synonyms: Formamide, N-2-pyrimidinyl- (6CI,9CI);Formamide, N-2-pyrimidinyl-;N-pyrimidin-2-ylformamide
• CAS NO: 31354-57-1
• Molecular Formula: C5H5N3O
• Molecular Weight: 123.1127
• Product Categories: PYRIMIDINE
• Mol File: 31354-57-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 168 °C(Solv: ethanol (64-17-5))
• Boiling Point: 285.6°Cat760mmHg
• Flash Point: 126.5°C
• Appearance: /
• Density: 1.328g/cm³
• Vapor Pressure: 0.00278mmHg at 25°C
• Refractive Index: 1.612
• PKA: 12.39±0.70(Predicted)
• CAS DataBase Reference: Formamide, N-2-pyrimidinyl- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-2-pyrimidinyl- (6CI,9CI)(31354-57-1)
• EPA Substance Registry System: Formamide, N-2-pyrimidinyl- (6CI,9CI)(31354-57-1)

Safety Data

• Hazardous Substances Data: 31354-57-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H5N3O/c9-4-8-5-6-2-1-3-7-5/h1-4H,(H,6,7,8,9)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 4774-33-8 tris(formylamino)methane 
• 88945-45-3 2-(5'-imino-2'-imidazolin-1'-yl)pyrimidine 
• 7440-44-0 pyrographite 
• 79917-54-7 nitro-pyrimidine 
• 37557-76-9 2-amino-4-(1',1'-dimethylacetonyl)amino-6-hydroxy-5-nitro-pyrimidine oxime 
• 64-18-6 formic acid 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Reagents for Bioorganic Synthesis: Preparation, Properties, and Reactions of Ethyl and Methyl N-(Cyanomethyl)methanimidates

An efficient procedure for the preparation of the reagents ethyl and methyl N-(cyanomethyl)methanimidates (NCCH2N=CHOR) (1a, R=Et; 1b, R=Me) is presented,along with their preliminary properties and reactions.The reaction of aminoacetonitrile hydrochloride with trialkyl orthoformate gave 4(5)-imidazolone.The reaction of aminoacetonitrile (free base) with the ortho ester, catalyzed by formic acid, gave methyl N-7H-imidazoimidazol-2-ylmethanimidate (6).The reaction of 1b with 2-aminothiazole and 2-aminopyrimidine, catalyzed by trimethylsilyl triflate, gave 2-(5'-imino-2'-imidazolin-1'-yl)thiazole (9) and 2-(5'-imino-2'-imidazolin-1'-yl)pyrimidine (10), respectively.Compound 10 underwent facile acid hydrolysis to form 2-(formylamino)pyrimidine (11).The reactions of 2-aminothiazole with 2 equiv of 1b or that of 10 with 1 equiv of 1b both provided 2-thiazole (12).

Facile N-formylation of amines using Lewis acids as novel catalysts

Alky, aryl, and heteroaryl amines were found to react efficiently with formic acid under Lewis acid catalysis giving N-formyl derivatives in high yields. A study of ZnCl2-catalyzed N-formylation of a variety of amines using formic acid as formylating agent is described.

Purine derivatives

Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. Also novel methods of manufacture for the derivatives, pharmaceutical compositions thereof, and methods of use therefor are the invention.