313681-20-8Relevant articles and documents
Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles
Miller, John F.,Brieger, Michael,Furfine, Eric S.,Hazen, Richard J.,Kaldor, Istvan,Reynolds, David,Sherrill, Ronald G.,Spaltenstein, Andrew
, p. 3496 - 3500 (2007/10/03)
A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the drug-resistant mutant viruses than they were against wild-type virus.