3137-60-8

Basic information

• Product Name: 4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI)
• Synonyms: 4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI);5-amino-6-chloro-1H-pyrimidin-4-one;5-azanyl-6-chloro-1H-pyrimidin-4-one;5-Amino-6-chloro-pyrimidin-4-ol ,97%;5-AMino-6-chloropyriMidin-4(1H)-one;5-amino-6-chloro-4(1H)-Pyrimidinone
• CAS NO: 3137-60-8
• Molecular Formula: C₄H₄ClN₃O
• Molecular Weight: 145.54706
• Product Categories: PYRIMIDINE
• Mol File: 3137-60-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 221-222 °C
• Boiling Point: 203.6°Cat760mmHg
• Flash Point: 77°C
• Appearance: /
• Density: 1.79g/cm³
• Vapor Pressure: 0.275mmHg at 25°C
• Refractive Index: 1.717
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.79±0.50(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI)(3137-60-8)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI)(3137-60-8)

Safety Data

• Hazardous Substances Data: 3137-60-8(Hazardous Substances Data)

Usage

General Description

4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI) is a chemical compound with the molecular formula C4H4ClN3O. It is a pyrimidine derivative with a chlorine atom attached to the sixth carbon and an amino group at the fifth carbon. 4(1H)-Pyrimidinone, 5-amino-6-chloro- (9CI) is used in organic synthesis and pharmaceutical research as a building block for the production of various pharmaceutical and agrochemical products. Additionally, it has potential biological activity and is being studied for its potential therapeutic applications in the treatment of various diseases. However,

InChI:InChI=1/C4H4ClN3O/c5-3-2(6)4(9)8-1-7-3/h1H,6H2,(H,7,8,9)

Upstream product

• 15846-19-2 4-methoxy-5-amino-6-chloropyrimidine 
• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 942149-14-6 (4-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl)methanol 
• 3137-56-2 6-chloro-5-nitro-pyrimidin-4-ol 

Downstream Products

• 85059-18-3 2-cyano-2-diazoacetamide 
• 85059-19-4 4-carbamoyl-5-chloro-1,2,3-triazole 
• 69785-94-0 5-Amino-4-hydroxypyrimidine 

Relevant articles and documents

Synthesis and biological evaluation of 6-substituted purinylcarbanucleosides with a cyclopenta[b]thiophene pseudosugar

The first members of a new family of heterocarbobicyclic nucleoside analogues have been synthesized from the cis/trans mixture of (4-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl)methanols (cis/trans-7). The separation of the cis and trans intermediates

Design, synthesis, and anticancer evaluation of acetamide and hydrazine analogues of pyrimidine

A library of acetamide and hydrazine analogues were generated on the pyrimidine ring through a multistep reaction starting from 5-nitro-pyrimidine-4,6-diol and pyrimidine-4,6-diol, respectively. The synthesized analogues were screened for in vitro cytotoxic activity against various human cancer cell lines like HCT-1 and HT-15 (colon), MCF-7(breast), PC-3 (prostrate), SF268 (CNS) using MTT method. From the bioassay results, it was observed that even though many of the synthesized derivatives exhibited a good potency against various screened cancer cell lines, compound 14a from the acetamide series was found to show potent anticancer activity on all the tested cancer cell lines with IC50 value of 0.36μM on CNS cell line and 1.6μM on HT-21 cell line, and compound 19xxi from hydrazine series of pyrimidine showed potent activity against three tested cancer cell lines with IC50 value of 0.76μM on HT-29 cell line, 2.6μM on HCT-15, and 3.2μM on MCF-7 cell line.