313737-28-9

Basic information

• Product Name: Butanoic acid, 4-[(4-bromo-2-formylphenyl)(1-methylethyl)amino]-
• CAS NO: 313737-28-9
• Molecular Formula: C14H18BrNO3
• Molecular Weight: 328.206
• Mol File: 313737-28-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-[(4-bromo-2-formylphenyl)(1-methylethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-[(4-bromo-2-formylphenyl)(1-methylethyl)amino]-(313737-28-9)
• EPA Substance Registry System: Butanoic acid, 4-[(4-bromo-2-formylphenyl)(1-methylethyl)amino]-(313737-28-9)

Safety Data

• Hazardous Substances Data: 313737-28-9(Hazardous Substances Data)

Upstream product

• 3772-26-7 N-isopropyl-2-pyrrolidone 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Relevant articles and documents

Facile synthesis of 7-10 membered rings by intramolecular condensation using dialkylcarbonate as solvent

A convenient large-scalable synthesis of 1-benzazepines 19 as an important intermediate of CCR5 antagonist, oral HIV-1 therapy, was established. The anilination of o-halogenobenzaldehyde 9 with alkylamino-acid 16 gave o-formylaniline-acid 17. Compound 17

BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally substituted hetero-alicyclic group.