313950-38-8Relevant articles and documents
Synthesis and structure - Activity relationship studies of novel dihydropyridones as androgen receptor modulators
Pepe, Antonella,Pamment, Michae,Kim, Yeong Sang,Lee, Sunmin,Lee, Min-Jung,Beebe, Kristin,Filikov, Anton,Neckers, Len,Trepel, Jane B.,Malhotra, Sanjay V.
, p. 8280 - 8297 (2013/12/04)
A library of 3-hydroxy-2,3-dihydropyridones was synthesized, and their activities as antiandrogens were tested in the human prostate cancer cell line LNCaP. Structure-activity relationship (SAR) studies resulted in the identification of a potent compound